Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

• Main Authors: Kaminska, K.K, Bertrand, H.C, Tajima, H, Stafford, W.C, Cheng, Q, Chen, W, Wells, G, Arner, E.S.J, Chew, E.-H
• Other Authors: PHARMACY
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: antineoplastic agent; apoptosis signal regulating kinase 1; caspase 3; glutathione peroxidase; glutathione reductase; indolin 2 one derivative; mitogen activated protein kinase p38; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; oxidoreductase inhibitor; selenocysteine; stress activated protein kinase; thioredoxin; unclassified drug; antioxidant; indole derivative; indolin-2-one; juglone; naphthoquinone; reactive oxygen metabolite; recombinant protein; thioredoxin reductase; TXN protein, human; antineoplastic activity; apoptosis; Article; breast carcinoma; carboxy terminal sequence; colorectal cancer; drug selectivity; drug structure; drug targeting; electrophilicity; enzyme activation; enzyme active site; enzyme inhibition; enzyme metabolism; HCT116 cell line; human; human cell; MCF 7 cell line; oxidative stress; protein cleavage; signal transduction; animal; antagonists and inhibitors; bovine; chemistry; drug design; drug screening; fibroblast; HCT 116 cell line; IC50; MCF-7 cell line; metabolism; mouse; protein domain; rat; Animals; Antineoplastic Agents; Antioxidants; Catalytic Domain; Cattle; Drug Design; Drug Screening Assays, Antitumor; Fibroblasts; Glutathione Peroxidase; Glutathione Reductase; HCT116 Cells; Humans; Indoles; Inhibitory Concentration 50; MCF-7 Cells; Mice; Naphthoquinones; Oxidative Stress; Protein Domains; Rats; Reactive Oxygen Species; Recombinant Proteins; Selenocysteine; Thioredoxin-Disulfide Reductase; Thioredoxins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175457
• Institution: National University of Singapore

10.18632/oncotarget.9579