Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model

• Main Authors: Jung, Y.Y, Shanmugam, M.K, Narula, A.S, Kim, C, Lee, J.H, Namjoshi, O.A, Blough, B.E, Sethi, G, Ahn, K.S
• Other Authors: DEPT OF PHARMACOLOGY
• Published: 2020
• Subjects: DNA; interleukin 6; Janus kinase 1; Janus kinase 2; matrine; oxymatrine; paclitaxel; protein tyrosine kinase; STAT5 protein; A-549 cell line; animal experiment; animal model; animal tissue; antineoplastic activity; antiproliferative activity; apoptosis; Article; cancer inhibition; cancer size; cancer survival; cell nucleus; cell proliferation; concentration response; controlled study; drug cytotoxicity; drug efficacy; drug mechanism; drug potentiation; drug structure; enzyme inhibition; female; G1 phase cell cycle checkpoint; human; human cell; in vitro study; in vivo study; mouse; mouse model; NCI-H1299 cell line; non small cell lung cancer; nonhuman; protein analysis; protein DNA binding; protein induction; protein localization; protein phosphorylation; signal transduction; tumor xenograft
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/177799
• Institution: National University of Singapore

10.3390/cancers11010049