Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model

10.3390/cancers11010049

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Main Authors:	Jung, Y.Y, Shanmugam, M.K, Narula, A.S, Kim, C, Lee, J.H, Namjoshi, O.A, Blough, B.E, Sethi, G, Ahn, K.S
Other Authors:	DEPT OF PHARMACOLOGY
Published:	2020
Subjects:	DNA interleukin 6 Janus kinase 1 Janus kinase 2 matrine oxymatrine paclitaxel protein tyrosine kinase STAT5 protein A-549 cell line animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis Article cancer inhibition cancer size cancer survival cell nucleus cell proliferation concentration response controlled study drug cytotoxicity drug efficacy drug mechanism drug potentiation drug structure enzyme inhibition female G1 phase cell cycle checkpoint human human cell in vitro study in vivo study mouse mouse model NCI-H1299 cell line non small cell lung cancer nonhuman protein analysis protein DNA binding protein induction protein localization protein phosphorylation signal transduction tumor xenograft
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/177799
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-177799
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spelling	sg-nus-scholar.10635-1777992021-09-22T17:31:21Z Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model Jung, Y.Y Shanmugam, M.K Narula, A.S Kim, C Lee, J.H Namjoshi, O.A Blough, B.E Sethi, G Ahn, K.S DEPT OF PHARMACOLOGY DNA interleukin 6 Janus kinase 1 Janus kinase 2 matrine oxymatrine paclitaxel protein tyrosine kinase STAT5 protein A-549 cell line animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis Article cancer inhibition cancer size cancer survival cell nucleus cell proliferation concentration response controlled study drug cytotoxicity drug efficacy drug mechanism drug potentiation drug structure enzyme inhibition female G1 phase cell cycle checkpoint human human cell in vitro study in vivo study mouse mouse model NCI-H1299 cell line non small cell lung cancer nonhuman protein analysis protein DNA binding protein induction protein localization protein phosphorylation signal transduction tumor xenograft 10.3390/cancers11010049 Cancers 11 1 49 2020-10-20T03:23:29Z 2020-10-20T03:23:29Z 2019 Jung, Y.Y, Shanmugam, M.K, Narula, A.S, Kim, C, Lee, J.H, Namjoshi, O.A, Blough, B.E, Sethi, G, Ahn, K.S (2019). Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model. Cancers 11 (1) : 49. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers11010049 20726694 https://scholarbank.nus.edu.sg/handle/10635/177799 Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	DNA interleukin 6 Janus kinase 1 Janus kinase 2 matrine oxymatrine paclitaxel protein tyrosine kinase STAT5 protein A-549 cell line animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis Article cancer inhibition cancer size cancer survival cell nucleus cell proliferation concentration response controlled study drug cytotoxicity drug efficacy drug mechanism drug potentiation drug structure enzyme inhibition female G1 phase cell cycle checkpoint human human cell in vitro study in vivo study mouse mouse model NCI-H1299 cell line non small cell lung cancer nonhuman protein analysis protein DNA binding protein induction protein localization protein phosphorylation signal transduction tumor xenograft
spellingShingle	DNA interleukin 6 Janus kinase 1 Janus kinase 2 matrine oxymatrine paclitaxel protein tyrosine kinase STAT5 protein A-549 cell line animal experiment animal model animal tissue antineoplastic activity antiproliferative activity apoptosis Article cancer inhibition cancer size cancer survival cell nucleus cell proliferation concentration response controlled study drug cytotoxicity drug efficacy drug mechanism drug potentiation drug structure enzyme inhibition female G1 phase cell cycle checkpoint human human cell in vitro study in vivo study mouse mouse model NCI-H1299 cell line non small cell lung cancer nonhuman protein analysis protein DNA binding protein induction protein localization protein phosphorylation signal transduction tumor xenograft Jung, Y.Y Shanmugam, M.K Narula, A.S Kim, C Lee, J.H Namjoshi, O.A Blough, B.E Sethi, G Ahn, K.S Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model
description	10.3390/cancers11010049
author2	DEPT OF PHARMACOLOGY
author_facet	DEPT OF PHARMACOLOGY Jung, Y.Y Shanmugam, M.K Narula, A.S Kim, C Lee, J.H Namjoshi, O.A Blough, B.E Sethi, G Ahn, K.S
author	Jung, Y.Y Shanmugam, M.K Narula, A.S Kim, C Lee, J.H Namjoshi, O.A Blough, B.E Sethi, G Ahn, K.S
author_sort	Jung, Y.Y
title	Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model
title_short	Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model
title_full	Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model
title_fullStr	Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model
title_full_unstemmed	Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model
title_sort	oxymatrine attenuates tumor growth and deactivates stat5 signaling in a lung cancer xenograft model
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/177799
_version_	1712300421313200128

Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model

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