Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma

• Main Authors: Kong, L.R, Tan, T.Z, Ong, W.R, Bi, C, Huynh, H, Lee, S.C, Chng, W.J, Eichhorn, P.J.A, Goh, B.C
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Wiley Blackwell 2020
• Subjects: B Raf kinase; belinostat; beta actin; caspase 3; cisplatin; F box protein; f box protein 3; f box protein W10; histone deacetylase 1; histone deacetylase 2; histone deacetylase 3; histone deacetylase 4; histone deacetylase 5; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; mitogen activated protein kinase p38; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; proteasome; protein c jun; protein kinase B; sirtuin 1; SOS protein; STAT2 protein; STAT3 protein; STAT5 protein; STAT6 protein; ubiquitin; unclassified drug; antineoplastic agent; hydroxamic acid; sulfonamide; tumor protein; animal cell; animal experiment; animal model; animal tissue; apoptosis; Article; cancer inhibition; cancer resistance; cancer size; cell proliferation; cell viability; chemosensitization; combination drug therapy; concentration response; controlled study; cytotoxicity; down regulation; drug potentiation; enzyme activation; enzyme degradation; enzyme phosphorylation; female; gene expression; histone acetylation; human; human cell; IC50; in vivo study; lung cancer cell line; mouse; nonhuman; nucleotide sequence; phosphoproteomics; priority journal; RNA interference; signal transduction; squamous cell carcinoma cell line; squamous cell lung carcinoma; transcription regulation; treatment duration; upregulation; drug effects; lung tumor; MAPK signaling; metabolism; pathology; squamous cell carcinoma; tumor cell line; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Hydroxamic Acids; Lung Neoplasms; MAP Kinase Signaling System; Neoplasm Proteins; Proteasome Endopeptidase Complex; Sulfonamides; Ubiquitin
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173836
• Institution: National University of Singapore

10.1002/1878-0261.12064