Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma

10.1002/1878-0261.12064

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Main Authors:	Kong, L.R, Tan, T.Z, Ong, W.R, Bi, C, Huynh, H, Lee, S.C, Chng, W.J, Eichhorn, P.J.A, Goh, B.C
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	Wiley Blackwell 2020
Subjects:	B Raf kinase belinostat beta actin caspase 3 cisplatin F box protein f box protein 3 f box protein W10 histone deacetylase 1 histone deacetylase 2 histone deacetylase 3 histone deacetylase 4 histone deacetylase 5 mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase kinase 1 mitogen activated protein kinase kinase 2 mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase proteasome protein c jun protein kinase B sirtuin 1 SOS protein STAT2 protein STAT3 protein STAT5 protein STAT6 protein ubiquitin unclassified drug antineoplastic agent hydroxamic acid sulfonamide tumor protein animal cell animal experiment animal model animal tissue apoptosis Article cancer inhibition cancer resistance cancer size cell proliferation cell viability chemosensitization combination drug therapy concentration response controlled study cytotoxicity down regulation drug potentiation enzyme activation enzyme degradation enzyme phosphorylation female gene expression histone acetylation human human cell IC50 in vivo study lung cancer cell line mouse nonhuman nucleotide sequence phosphoproteomics priority journal RNA interference signal transduction squamous cell carcinoma cell line squamous cell lung carcinoma transcription regulation treatment duration upregulation drug effects lung tumor MAPK signaling metabolism pathology squamous cell carcinoma tumor cell line Antineoplastic Agents Carcinoma, Squamous Cell Cell Line, Tumor Humans Hydroxamic Acids Lung Neoplasms MAP Kinase Signaling System Neoplasm Proteins Proteasome Endopeptidase Complex Sulfonamides Ubiquitin
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173836
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1738362024-04-18T03:09:11Z Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma Kong, L.R Tan, T.Z Ong, W.R Bi, C Huynh, H Lee, S.C Chng, W.J Eichhorn, P.J.A Goh, B.C CANCER SCIENCE INSTITUTE OF SINGAPORE MEDICINE PHARMACOLOGY B Raf kinase belinostat beta actin caspase 3 cisplatin F box protein f box protein 3 f box protein W10 histone deacetylase 1 histone deacetylase 2 histone deacetylase 3 histone deacetylase 4 histone deacetylase 5 mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase kinase 1 mitogen activated protein kinase kinase 2 mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase proteasome protein c jun protein kinase B sirtuin 1 SOS protein STAT2 protein STAT3 protein STAT5 protein STAT6 protein ubiquitin unclassified drug antineoplastic agent belinostat hydroxamic acid proteasome sulfonamide tumor protein ubiquitin animal cell animal experiment animal model animal tissue apoptosis Article cancer inhibition cancer resistance cancer size cell proliferation cell viability chemosensitization combination drug therapy concentration response controlled study cytotoxicity down regulation drug potentiation enzyme activation enzyme degradation enzyme phosphorylation female gene expression histone acetylation human human cell IC50 in vivo study lung cancer cell line mouse nonhuman nucleotide sequence phosphoproteomics priority journal RNA interference signal transduction squamous cell carcinoma cell line squamous cell lung carcinoma transcription regulation treatment duration upregulation drug effects lung tumor MAPK signaling metabolism pathology squamous cell carcinoma tumor cell line Antineoplastic Agents Carcinoma, Squamous Cell Cell Line, Tumor Humans Hydroxamic Acids Lung Neoplasms MAP Kinase Signaling System Neoplasm Proteins Proteasome Endopeptidase Complex Sulfonamides Ubiquitin 10.1002/1878-0261.12064 Molecular Oncology 11 8 965-980 2020-09-01T07:51:50Z 2020-09-01T07:51:50Z 2017-07 Article Kong, L.R, Tan, T.Z, Ong, W.R, Bi, C, Huynh, H, Lee, S.C, Chng, W.J, Eichhorn, P.J.A, Goh, B.C (2017-07). Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma. Molecular Oncology 11 (8) : 965-980. ScholarBank@NUS Repository. https://doi.org/10.1002/1878-0261.12064 15747891 https://scholarbank.nus.edu.sg/handle/10635/173836 Wiley Blackwell Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	B Raf kinase belinostat beta actin caspase 3 cisplatin F box protein f box protein 3 f box protein W10 histone deacetylase 1 histone deacetylase 2 histone deacetylase 3 histone deacetylase 4 histone deacetylase 5 mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase kinase 1 mitogen activated protein kinase kinase 2 mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase proteasome protein c jun protein kinase B sirtuin 1 SOS protein STAT2 protein STAT3 protein STAT5 protein STAT6 protein ubiquitin unclassified drug antineoplastic agent belinostat hydroxamic acid proteasome sulfonamide tumor protein ubiquitin animal cell animal experiment animal model animal tissue apoptosis Article cancer inhibition cancer resistance cancer size cell proliferation cell viability chemosensitization combination drug therapy concentration response controlled study cytotoxicity down regulation drug potentiation enzyme activation enzyme degradation enzyme phosphorylation female gene expression histone acetylation human human cell IC50 in vivo study lung cancer cell line mouse nonhuman nucleotide sequence phosphoproteomics priority journal RNA interference signal transduction squamous cell carcinoma cell line squamous cell lung carcinoma transcription regulation treatment duration upregulation drug effects lung tumor MAPK signaling metabolism pathology squamous cell carcinoma tumor cell line Antineoplastic Agents Carcinoma, Squamous Cell Cell Line, Tumor Humans Hydroxamic Acids Lung Neoplasms MAP Kinase Signaling System Neoplasm Proteins Proteasome Endopeptidase Complex Sulfonamides Ubiquitin
spellingShingle	B Raf kinase belinostat beta actin caspase 3 cisplatin F box protein f box protein 3 f box protein W10 histone deacetylase 1 histone deacetylase 2 histone deacetylase 3 histone deacetylase 4 histone deacetylase 5 mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase kinase 1 mitogen activated protein kinase kinase 2 mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase proteasome protein c jun protein kinase B sirtuin 1 SOS protein STAT2 protein STAT3 protein STAT5 protein STAT6 protein ubiquitin unclassified drug antineoplastic agent belinostat hydroxamic acid proteasome sulfonamide tumor protein ubiquitin animal cell animal experiment animal model animal tissue apoptosis Article cancer inhibition cancer resistance cancer size cell proliferation cell viability chemosensitization combination drug therapy concentration response controlled study cytotoxicity down regulation drug potentiation enzyme activation enzyme degradation enzyme phosphorylation female gene expression histone acetylation human human cell IC50 in vivo study lung cancer cell line mouse nonhuman nucleotide sequence phosphoproteomics priority journal RNA interference signal transduction squamous cell carcinoma cell line squamous cell lung carcinoma transcription regulation treatment duration upregulation drug effects lung tumor MAPK signaling metabolism pathology squamous cell carcinoma tumor cell line Antineoplastic Agents Carcinoma, Squamous Cell Cell Line, Tumor Humans Hydroxamic Acids Lung Neoplasms MAP Kinase Signaling System Neoplasm Proteins Proteasome Endopeptidase Complex Sulfonamides Ubiquitin Kong, L.R Tan, T.Z Ong, W.R Bi, C Huynh, H Lee, S.C Chng, W.J Eichhorn, P.J.A Goh, B.C Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma
description	10.1002/1878-0261.12064
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Kong, L.R Tan, T.Z Ong, W.R Bi, C Huynh, H Lee, S.C Chng, W.J Eichhorn, P.J.A Goh, B.C
format	Article
author	Kong, L.R Tan, T.Z Ong, W.R Bi, C Huynh, H Lee, S.C Chng, W.J Eichhorn, P.J.A Goh, B.C
author_sort	Kong, L.R
title	Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma
title_short	Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma
title_full	Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma
title_fullStr	Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma
title_full_unstemmed	Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma
title_sort	belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma
publisher	Wiley Blackwell
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/173836
_version_	1800914194333171712

Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma

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