Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma

Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma

10.1002/1878-0261.12064

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Bibliographic Details
Main Authors:	Kong, L.R, Tan, T.Z, Ong, W.R, Bi, C, Huynh, H, Lee, S.C, Chng, W.J, Eichhorn, P.J.A, Goh, B.C
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	Wiley Blackwell 2020
Subjects:	B Raf kinase belinostat beta actin caspase 3 cisplatin F box protein f box protein 3 f box protein W10 histone deacetylase 1 histone deacetylase 2 histone deacetylase 3 histone deacetylase 4 histone deacetylase 5 mitogen activated protein kinase mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase kinase 1 mitogen activated protein kinase kinase 2 mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase proteasome protein c jun protein kinase B sirtuin 1 SOS protein STAT2 protein STAT3 protein STAT5 protein STAT6 protein ubiquitin unclassified drug antineoplastic agent hydroxamic acid sulfonamide tumor protein animal cell animal experiment animal model animal tissue apoptosis Article cancer inhibition cancer resistance cancer size cell proliferation cell viability chemosensitization combination drug therapy concentration response controlled study cytotoxicity down regulation drug potentiation enzyme activation enzyme degradation enzyme phosphorylation female gene expression histone acetylation human human cell IC50 in vivo study lung cancer cell line mouse nonhuman nucleotide sequence phosphoproteomics priority journal RNA interference signal transduction squamous cell carcinoma cell line squamous cell lung carcinoma transcription regulation treatment duration upregulation drug effects lung tumor MAPK signaling metabolism pathology squamous cell carcinoma tumor cell line Antineoplastic Agents Carcinoma, Squamous Cell Cell Line, Tumor Humans Hydroxamic Acids Lung Neoplasms MAP Kinase Signaling System Neoplasm Proteins Proteasome Endopeptidase Complex Sulfonamides Ubiquitin
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173836
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Institution:	National University of Singapore

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