Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatinresistant cancer cells

• Main Authors: Seah, S, Low, I, Hirpara, J.L, Sachaphibulkij, K, Kroemer, G, Brenner, C, Pervaiz, S
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: cisplatin; death receptor; inducible nitric oxide synthase; nitric oxide; peroxynitrite; reactive nitrogen species; tumor necrosis factor related apoptosis inducing ligand; antineoplastic agent; peroxynitrous acid; TNFRSF10A protein, human; tumor necrosis factor related apoptosis inducing ligand receptor; a2780 cell line; A549 cell line; apoptosis; Article; cancer cell; cancer chemotherapy; cancer resistance; cell death; cell membrane; cross resistance; disease association; DNA fragmentation; drug potentiation; female; genetic transcription; h2030 cell line; human; human cell; lipid raft; lung cancer cell line; mitochondrial respiration; non small cell lung cancer; ovarian cancer cell line; priority journal; signal transduction; upregulation; drug effects; drug resistance; metabolism; protein transport; tumor cell line; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Humans; Membrane Microdomains; Peroxynitrous Acid; Protein Transport; Reactive Nitrogen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175479
• Institution: National University of Singapore

10.1038/cddis.2015.299