Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma

• Main Authors: Pin, Y.K, Khoo, K, Tham, M, Karwai, T, Hwee, T.C, Puaux, A.-L, Phua, M.L.C, Kato, M, Angeli, V, Abastado, J.-P
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: celecoxib; dexamethasone plus tobramycin; protein kinase B; vasculotropin A; vasculotropin receptor 1; cyclooxygenase 2 inhibitor; protein Ret; RET protein, human; vascular endothelial growth factor A, mouse; animal cell; animal experiment; animal model; animal tissue; Article; cancer cell; cancer growth; cancer inhibition; cancer survival; carcinogenesis; controlled study; enzyme phosphorylation; female; lymph node dissection; lymphangiogenesis; male; metastasis; mouse; mouse model; nonhuman; oncological parameters; protein expression; tumor growth; tumor homeostasis; tumor microenvironment; uvea melanoma; adverse effects; animal; cell motion; cell proliferation; disease course; drug effects; genetic predisposition; genetics; human; melanoma; metabolism; Neoplasms, Experimental; neovascularization (pathology); pathology; phenotype; phosphorylation; secondary; time factor; transgenic mouse; tumor volume; Uveal Neoplasms; Animals; Cell Movement; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Disease Progression; Female; Genetic Predisposition to Disease; Humans; Lymph Node Excision; Male; Melanoma; Mice; Mice, Transgenic; Neovascularization, Pathologic; Phenotype; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Time Factors; Tumor Burden; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175519
• Institution: National University of Singapore

10.18632/oncotarget.6326