Comparison of diabetic and non-diabetic human leukocytic responses to different capsule types of Klebsiella pneumoniae responsible for causing pyogenic liver abscess

• Main Authors: Lee, I.R, Sng, E, Lee, K.-O, Molton, J.S, Chan, M, Kalimuddin, S, Izharuddin, E, Lye, D.C, Archuleta, S, Gan, Y.-H
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: antibiotic agent; gamma interferon; glucose; hemoglobin A1c; interleukin 10; interleukin 12; interleukin 17; interleukin 1beta; interleukin 6; bacterial antigen; bacterial DNA; bacterial polysaccharide; capsular polysaccharide K1; chemokine; cytokine; peroxidase; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2; virulence factor; Article; bacterial infection; bactericidal activity; controlled study; cytokine production; cytokine response; enzyme linked immunosorbent assay; extracellular trap; flow cytometry; glycemic control; human; human experiment; immunofluorescence microscopy; innate immunity; Klebsiella pneumoniae; leukocyte activation; non insulin dependent diabetes mellitus; nonhuman; peripheral blood mononuclear cell; phagocytosis; pyogenic liver abscess; adult; aged; bacterial capsule; blood; complication; immunology; Klebsiella infection; metabolism; microbiology; middle aged; mononuclear cell; neutrophil; pathogenicity; serum bactericidal activity; Adult; Aged; Antigens, Bacterial; Bacterial Capsules; Blood Bactericidal Activity; Chemokines; Cytokines; Diabetes Mellitus, Type 2; DNA, Bacterial; Extracellular Traps; Humans; Interferon-gamma; Interleukin-12; Klebsiella Infections; Leukocytes, Mononuclear; Liver Abscess, Pyogenic; Middle Aged; Neutrophils; Peroxidase; Phagocytosis; Polysaccharides, Bacterial; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Virulence Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/176080
• Institution: National University of Singapore

10.3389/fcimb.2017.00401