Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis

• Main Authors: Gopal, P, Yee, M, Sarathy, J, Liang Low, J, Sarathy, J.P, Kaya, F, Dartois, V, Gengenbacher, M, Dick, T
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: acyl carrier coenzyme A; aspartate decarboxylase; benzoic acid; ciprofloxacin; coenzyme A; fatty acid synthase; isoniazid; nicotinic acid; phthiocerol dimycocerosate; polyketide synthase; pyrazinoic acid; ribosome protein; ribosome protein S1; rifampicin; streptomycin; unclassified drug; virulence factor; aspartate 4-decarboxylase; bacterial protein; carboxylyase; pyrazinamide; antibiotic resistance; antibiotic sensitivity; Article; bacterial strain; bacterium isolation; carboxy terminal sequence; controlled study; cross resistance; frameshift mutation; in vitro study; loss of function mutation; minimum inhibitory concentration; missense mutation; mutation rate; Mycobacterium bovis BCG; Mycobacterium tuberculosis; nonhuman; point mutation; priority journal; whole genome sequencing; biosynthesis; drug effects; genetics; human; metabolism; microbiology; Mycobacterium bovis; tuberculosis; Bacterial Proteins; Carboxy-Lyases; Coenzyme A; Drug Resistance, Bacterial; Humans; Mutation, Missense; Polyketide Synthases; Pyrazinamide; Tuberculosis; Virulence Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/176213
• Institution: National University of Singapore

10.1021/acsinfecdis.6b00070