Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis

10.1021/acsinfecdis.6b00070

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Main Authors:	Gopal, P, Yee, M, Sarathy, J, Liang Low, J, Sarathy, J.P, Kaya, F, Dartois, V, Gengenbacher, M, Dick, T
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	acyl carrier coenzyme A aspartate decarboxylase benzoic acid ciprofloxacin coenzyme A fatty acid synthase isoniazid nicotinic acid phthiocerol dimycocerosate polyketide synthase pyrazinoic acid ribosome protein ribosome protein S1 rifampicin streptomycin unclassified drug virulence factor aspartate 4-decarboxylase bacterial protein carboxylyase pyrazinamide antibiotic resistance antibiotic sensitivity Article bacterial strain bacterium isolation carboxy terminal sequence controlled study cross resistance frameshift mutation in vitro study loss of function mutation minimum inhibitory concentration missense mutation mutation rate Mycobacterium bovis BCG Mycobacterium tuberculosis nonhuman point mutation priority journal whole genome sequencing biosynthesis drug effects genetics human metabolism microbiology Mycobacterium bovis tuberculosis Bacterial Proteins Carboxy-Lyases Coenzyme A Drug Resistance, Bacterial Humans Mutation, Missense Polyketide Synthases Pyrazinamide Tuberculosis Virulence Factors
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/176213
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1762132024-11-14T06:11:00Z Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis Gopal, P Yee, M Sarathy, J Liang Low, J Sarathy, J.P Kaya, F Dartois, V Gengenbacher, M Dick, T MEDICINE MICROBIOLOGY AND IMMUNOLOGY acyl carrier coenzyme A aspartate decarboxylase benzoic acid ciprofloxacin coenzyme A fatty acid synthase isoniazid nicotinic acid phthiocerol dimycocerosate polyketide synthase pyrazinoic acid ribosome protein ribosome protein S1 rifampicin streptomycin unclassified drug virulence factor aspartate 4-decarboxylase bacterial protein carboxylyase coenzyme A pyrazinamide virulence factor antibiotic resistance antibiotic sensitivity Article bacterial strain bacterium isolation carboxy terminal sequence controlled study cross resistance frameshift mutation in vitro study loss of function mutation minimum inhibitory concentration missense mutation mutation rate Mycobacterium bovis BCG Mycobacterium tuberculosis nonhuman point mutation priority journal whole genome sequencing antibiotic resistance biosynthesis drug effects genetics human metabolism microbiology Mycobacterium bovis tuberculosis Bacterial Proteins Carboxy-Lyases Coenzyme A Drug Resistance, Bacterial Humans Mutation, Missense Mycobacterium bovis Mycobacterium tuberculosis Polyketide Synthases Pyrazinamide Tuberculosis Virulence Factors 10.1021/acsinfecdis.6b00070 ACS Infectious Diseases 2 9 616-626 2020-09-14T08:31:01Z 2020-09-14T08:31:01Z 2016 Article Gopal, P, Yee, M, Sarathy, J, Liang Low, J, Sarathy, J.P, Kaya, F, Dartois, V, Gengenbacher, M, Dick, T (2016). Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis. ACS Infectious Diseases 2 (9) : 616-626. ScholarBank@NUS Repository. https://doi.org/10.1021/acsinfecdis.6b00070 2373-8227 https://scholarbank.nus.edu.sg/handle/10635/176213 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	acyl carrier coenzyme A aspartate decarboxylase benzoic acid ciprofloxacin coenzyme A fatty acid synthase isoniazid nicotinic acid phthiocerol dimycocerosate polyketide synthase pyrazinoic acid ribosome protein ribosome protein S1 rifampicin streptomycin unclassified drug virulence factor aspartate 4-decarboxylase bacterial protein carboxylyase coenzyme A pyrazinamide virulence factor antibiotic resistance antibiotic sensitivity Article bacterial strain bacterium isolation carboxy terminal sequence controlled study cross resistance frameshift mutation in vitro study loss of function mutation minimum inhibitory concentration missense mutation mutation rate Mycobacterium bovis BCG Mycobacterium tuberculosis nonhuman point mutation priority journal whole genome sequencing antibiotic resistance biosynthesis drug effects genetics human metabolism microbiology Mycobacterium bovis tuberculosis Bacterial Proteins Carboxy-Lyases Coenzyme A Drug Resistance, Bacterial Humans Mutation, Missense Mycobacterium bovis Mycobacterium tuberculosis Polyketide Synthases Pyrazinamide Tuberculosis Virulence Factors
spellingShingle	acyl carrier coenzyme A aspartate decarboxylase benzoic acid ciprofloxacin coenzyme A fatty acid synthase isoniazid nicotinic acid phthiocerol dimycocerosate polyketide synthase pyrazinoic acid ribosome protein ribosome protein S1 rifampicin streptomycin unclassified drug virulence factor aspartate 4-decarboxylase bacterial protein carboxylyase coenzyme A pyrazinamide virulence factor antibiotic resistance antibiotic sensitivity Article bacterial strain bacterium isolation carboxy terminal sequence controlled study cross resistance frameshift mutation in vitro study loss of function mutation minimum inhibitory concentration missense mutation mutation rate Mycobacterium bovis BCG Mycobacterium tuberculosis nonhuman point mutation priority journal whole genome sequencing antibiotic resistance biosynthesis drug effects genetics human metabolism microbiology Mycobacterium bovis tuberculosis Bacterial Proteins Carboxy-Lyases Coenzyme A Drug Resistance, Bacterial Humans Mutation, Missense Mycobacterium bovis Mycobacterium tuberculosis Polyketide Synthases Pyrazinamide Tuberculosis Virulence Factors Gopal, P Yee, M Sarathy, J Liang Low, J Sarathy, J.P Kaya, F Dartois, V Gengenbacher, M Dick, T Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis
description	10.1021/acsinfecdis.6b00070
author2	MEDICINE
author_facet	MEDICINE Gopal, P Yee, M Sarathy, J Liang Low, J Sarathy, J.P Kaya, F Dartois, V Gengenbacher, M Dick, T
format	Article
author	Gopal, P Yee, M Sarathy, J Liang Low, J Sarathy, J.P Kaya, F Dartois, V Gengenbacher, M Dick, T
author_sort	Gopal, P
title	Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis
title_short	Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis
title_full	Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis
title_fullStr	Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis
title_full_unstemmed	Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis
title_sort	pyrazinamide resistance is caused by two distinct mechanisms: prevention of coenzyme a depletion and loss of virulence factor synthesis
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/176213
_version_	1821234215715340288

Pyrazinamide resistance is caused by two distinct mechanisms: Prevention of coenzyme a depletion and loss of virulence factor synthesis

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