Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

• Main Authors: Pritchard, C.C, Morrissey, C, Kumar, A, Zhang, X, Smith, C, Coleman, I, Salipante, S.J, Milbank, J, Yu, M, Grady, W.M, Tait, J.F, Corey, E, Vessella, R.L, Walsh, T, Shendure, J, Nelson, P.S
• Other Authors: ELECTRICAL AND COMPUTER ENGINEERING
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: protein MSH2; protein MSH6; DNA binding protein; G-T mismatch-binding protein; MSH2 protein, human; protein binding; cancer; disease incidence; gene expression; genetic differentiation; microstructure; mutation; advanced cancer; Article; autopsy; bioinformatics; cancer growth; controlled study; copy number variation; disease assessment; disease association; DNA repair; frameshift mutation; gene mutation; gene rearrangement; human; human tissue; loss of function mutation; male; microsatellite instability; mismatch repair; prostate cancer; protein expression; enzymology; genetics; metabolism; middle aged; prostate tumor; DNA Mismatch Repair; DNA-Binding Proteins; Humans; Male; Microsatellite Instability; Middle Aged; Mutation; MutS Homolog 2 Protein; Prostatic Neoplasms; Protein Binding
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/177773
• Institution: National University of Singapore

10.1038/ncomms5988