Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

10.1186/ar2365

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Main Authors:	Milici, A.J, Kudlacz, E.M, Audoly, L, Zwillich, S, Changelian, P
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	4 [n [1 (2 cyano 1 oxoethyl) 4 methyl 3 piperidinyl] n methylamino]pyrrolo[2,3 d]pyrimidine interleukin 6 Janus kinase 3 tumor necrosis factor antibody collagen CP 690,550 CP-690,550 enzyme inhibitor immunological adjuvant pyrimidine derivative pyrrole derivative adjuvant arthritis animal cell animal experiment animal model animal tissue article chondroprotection controlled study DBA 1 mouse dose response drug blood level drug dose comparison drug efficacy drug megadose drug targeting enzyme inhibition Lewis rat low drug dose male mouse nonhuman paw edema protein blood level rat rheumatoid arthritis scoring system animal arthritis articular cartilage blood DBA mouse drug antagonism enzymology immunology pathology Adjuvants, Immunologic Animals Arthritis, Experimental Arthritis, Rheumatoid Cartilage, Articular Collagen Dose-Response Relationship, Drug Enzyme Inhibitors Interleukin-6 Janus Kinase 3 Male Mice Mice, Inbred DBA Pyrimidines Pyrroles Rats Rats, Inbred Lew
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/177981
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1779812023-11-01T08:29:12Z Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis Milici, A.J Kudlacz, E.M Audoly, L Zwillich, S Changelian, P DUKE-NUS MEDICAL SCHOOL 4 [n [1 (2 cyano 1 oxoethyl) 4 methyl 3 piperidinyl] n methylamino]pyrrolo[2,3 d]pyrimidine interleukin 6 Janus kinase 3 tumor necrosis factor antibody collagen CP 690,550 CP-690,550 enzyme inhibitor immunological adjuvant interleukin 6 Janus kinase 3 pyrimidine derivative pyrrole derivative adjuvant arthritis animal cell animal experiment animal model animal tissue article chondroprotection controlled study DBA 1 mouse dose response drug blood level drug dose comparison drug efficacy drug megadose drug targeting enzyme inhibition Lewis rat low drug dose male mouse nonhuman paw edema protein blood level rat rheumatoid arthritis scoring system animal arthritis articular cartilage blood DBA mouse drug antagonism enzymology immunology pathology rheumatoid arthritis Adjuvants, Immunologic Animals Arthritis, Experimental Arthritis, Rheumatoid Cartilage, Articular Collagen Dose-Response Relationship, Drug Enzyme Inhibitors Interleukin-6 Janus Kinase 3 Male Mice Mice, Inbred DBA Pyrimidines Pyrroles Rats Rats, Inbred Lew 10.1186/ar2365 Arthritis Research and Therapy 10 1 R14 2020-10-20T04:44:10Z 2020-10-20T04:44:10Z 2008 Article Milici, A.J, Kudlacz, E.M, Audoly, L, Zwillich, S, Changelian, P (2008). Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Arthritis Research and Therapy 10 (1) : R14. ScholarBank@NUS Repository. https://doi.org/10.1186/ar2365 14786354 https://scholarbank.nus.edu.sg/handle/10635/177981 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	4 [n [1 (2 cyano 1 oxoethyl) 4 methyl 3 piperidinyl] n methylamino]pyrrolo[2,3 d]pyrimidine interleukin 6 Janus kinase 3 tumor necrosis factor antibody collagen CP 690,550 CP-690,550 enzyme inhibitor immunological adjuvant interleukin 6 Janus kinase 3 pyrimidine derivative pyrrole derivative adjuvant arthritis animal cell animal experiment animal model animal tissue article chondroprotection controlled study DBA 1 mouse dose response drug blood level drug dose comparison drug efficacy drug megadose drug targeting enzyme inhibition Lewis rat low drug dose male mouse nonhuman paw edema protein blood level rat rheumatoid arthritis scoring system animal arthritis articular cartilage blood DBA mouse drug antagonism enzymology immunology pathology rheumatoid arthritis Adjuvants, Immunologic Animals Arthritis, Experimental Arthritis, Rheumatoid Cartilage, Articular Collagen Dose-Response Relationship, Drug Enzyme Inhibitors Interleukin-6 Janus Kinase 3 Male Mice Mice, Inbred DBA Pyrimidines Pyrroles Rats Rats, Inbred Lew
spellingShingle	4 [n [1 (2 cyano 1 oxoethyl) 4 methyl 3 piperidinyl] n methylamino]pyrrolo[2,3 d]pyrimidine interleukin 6 Janus kinase 3 tumor necrosis factor antibody collagen CP 690,550 CP-690,550 enzyme inhibitor immunological adjuvant interleukin 6 Janus kinase 3 pyrimidine derivative pyrrole derivative adjuvant arthritis animal cell animal experiment animal model animal tissue article chondroprotection controlled study DBA 1 mouse dose response drug blood level drug dose comparison drug efficacy drug megadose drug targeting enzyme inhibition Lewis rat low drug dose male mouse nonhuman paw edema protein blood level rat rheumatoid arthritis scoring system animal arthritis articular cartilage blood DBA mouse drug antagonism enzymology immunology pathology rheumatoid arthritis Adjuvants, Immunologic Animals Arthritis, Experimental Arthritis, Rheumatoid Cartilage, Articular Collagen Dose-Response Relationship, Drug Enzyme Inhibitors Interleukin-6 Janus Kinase 3 Male Mice Mice, Inbred DBA Pyrimidines Pyrroles Rats Rats, Inbred Lew Milici, A.J Kudlacz, E.M Audoly, L Zwillich, S Changelian, P Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
description	10.1186/ar2365
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Milici, A.J Kudlacz, E.M Audoly, L Zwillich, S Changelian, P
format	Article
author	Milici, A.J Kudlacz, E.M Audoly, L Zwillich, S Changelian, P
author_sort	Milici, A.J
title	Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
title_short	Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
title_full	Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
title_fullStr	Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
title_full_unstemmed	Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
title_sort	cartilage preservation by inhibition of janus kinase 3 in two rodent models of rheumatoid arthritis
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/177981
_version_	1781792255644794880

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

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