Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

• Main Authors: Milici, A.J, Kudlacz, E.M, Audoly, L, Zwillich, S, Changelian, P
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: 4 [n [1 (2 cyano 1 oxoethyl) 4 methyl 3 piperidinyl] n methylamino]pyrrolo[2,3 d]pyrimidine; interleukin 6; Janus kinase 3; tumor necrosis factor antibody; collagen; CP 690,550; CP-690,550; enzyme inhibitor; immunological adjuvant; pyrimidine derivative; pyrrole derivative; adjuvant arthritis; animal cell; animal experiment; animal model; animal tissue; article; chondroprotection; controlled study; DBA 1 mouse; dose response; drug blood level; drug dose comparison; drug efficacy; drug megadose; drug targeting; enzyme inhibition; Lewis rat; low drug dose; male; mouse; nonhuman; paw edema; protein blood level; rat; rheumatoid arthritis; scoring system; animal; arthritis; articular cartilage; blood; DBA mouse; drug antagonism; enzymology; immunology; pathology; Adjuvants, Immunologic; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Collagen; Dose-Response Relationship, Drug; Enzyme Inhibitors; Interleukin-6; Janus Kinase 3; Male; Mice; Mice, Inbred DBA; Pyrimidines; Pyrroles; Rats; Rats, Inbred Lew
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/177981
• Institution: National University of Singapore

10.1186/ar2365