Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

10.1186/1471-2148-7-78

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Main Authors:	Rausch, C, Hoof, I, Weber, T, Wohlleben, W, Huson, D.H
Other Authors:	LIFE SCIENCES INSTITUTE
Format:	Article
Published:	2020
Subjects:	alpha amanitin amino acid derivative beta hydroxycarboxylic acid beta hydroxyl fatty acid bleomycin cyclosporin A cysteine non ribosomal peptide synthase penicillin G peptide synthase serine threonine unclassified drug vancomycin non-ribosomal peptide synthase article catalysis cyclization enzyme structure enzyme synthesis epimerization hidden Markov model molecular evolution nonhuman nonribosomal peptide synthesis peptide analysis phylogeny polymerization protein domain protein motif statistical model amino acid sequence bacterial genome bacterium classification enzyme specificity gene expression regulation genetics protein tertiary structure sequence alignment Amino Acid Motifs Amino Acid Sequence Bacteria Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Genome, Bacterial Peptide Synthases Phylogeny Protein Structure, Tertiary Sequence Alignment Substrate Specificity
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/177993
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-177993
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spelling	sg-nus-scholar.10635-1779932023-11-01T08:28:13Z Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution Rausch, C Hoof, I Weber, T Wohlleben, W Huson, D.H LIFE SCIENCES INSTITUTE alpha amanitin amino acid derivative beta hydroxycarboxylic acid beta hydroxyl fatty acid bleomycin cyclosporin A cysteine non ribosomal peptide synthase penicillin G peptide synthase serine threonine unclassified drug vancomycin non ribosomal peptide synthase non-ribosomal peptide synthase peptide synthase article catalysis cyclization enzyme structure enzyme synthesis epimerization hidden Markov model molecular evolution nonhuman nonribosomal peptide synthesis peptide analysis phylogeny polymerization protein domain protein motif statistical model amino acid sequence bacterial genome bacterium classification enzyme specificity gene expression regulation genetics protein tertiary structure sequence alignment Amino Acid Motifs Amino Acid Sequence Bacteria Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Genome, Bacterial Peptide Synthases Phylogeny Protein Structure, Tertiary Sequence Alignment Substrate Specificity 10.1186/1471-2148-7-78 BMC Evolutionary Biology 7 78 2020-10-20T04:46:17Z 2020-10-20T04:46:17Z 2007 Article Rausch, C, Hoof, I, Weber, T, Wohlleben, W, Huson, D.H (2007). Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution. BMC Evolutionary Biology 7 : 78. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2148-7-78 14712148 https://scholarbank.nus.edu.sg/handle/10635/177993 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	alpha amanitin amino acid derivative beta hydroxycarboxylic acid beta hydroxyl fatty acid bleomycin cyclosporin A cysteine non ribosomal peptide synthase penicillin G peptide synthase serine threonine unclassified drug vancomycin non ribosomal peptide synthase non-ribosomal peptide synthase peptide synthase article catalysis cyclization enzyme structure enzyme synthesis epimerization hidden Markov model molecular evolution nonhuman nonribosomal peptide synthesis peptide analysis phylogeny polymerization protein domain protein motif statistical model amino acid sequence bacterial genome bacterium classification enzyme specificity gene expression regulation genetics protein tertiary structure sequence alignment Amino Acid Motifs Amino Acid Sequence Bacteria Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Genome, Bacterial Peptide Synthases Phylogeny Protein Structure, Tertiary Sequence Alignment Substrate Specificity
spellingShingle	alpha amanitin amino acid derivative beta hydroxycarboxylic acid beta hydroxyl fatty acid bleomycin cyclosporin A cysteine non ribosomal peptide synthase penicillin G peptide synthase serine threonine unclassified drug vancomycin non ribosomal peptide synthase non-ribosomal peptide synthase peptide synthase article catalysis cyclization enzyme structure enzyme synthesis epimerization hidden Markov model molecular evolution nonhuman nonribosomal peptide synthesis peptide analysis phylogeny polymerization protein domain protein motif statistical model amino acid sequence bacterial genome bacterium classification enzyme specificity gene expression regulation genetics protein tertiary structure sequence alignment Amino Acid Motifs Amino Acid Sequence Bacteria Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Genome, Bacterial Peptide Synthases Phylogeny Protein Structure, Tertiary Sequence Alignment Substrate Specificity Rausch, C Hoof, I Weber, T Wohlleben, W Huson, D.H Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
description	10.1186/1471-2148-7-78
author2	LIFE SCIENCES INSTITUTE
author_facet	LIFE SCIENCES INSTITUTE Rausch, C Hoof, I Weber, T Wohlleben, W Huson, D.H
format	Article
author	Rausch, C Hoof, I Weber, T Wohlleben, W Huson, D.H
author_sort	Rausch, C
title	Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
title_short	Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
title_full	Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
title_fullStr	Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
title_full_unstemmed	Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
title_sort	phylogenetic analysis of condensation domains in nrps sheds light on their functional evolution
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/177993
_version_	1781792257898184704

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

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