Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

• Main Authors: Rausch, C, Hoof, I, Weber, T, Wohlleben, W, Huson, D.H
• Other Authors: LIFE SCIENCES INSTITUTE
• Format: Article
• Published: 2020
• Subjects: alpha amanitin; amino acid derivative; beta hydroxycarboxylic acid; beta hydroxyl fatty acid; bleomycin; cyclosporin A; cysteine; non ribosomal peptide synthase; penicillin G; peptide synthase; serine; threonine; unclassified drug; vancomycin; non-ribosomal peptide synthase; article; catalysis; cyclization; enzyme structure; enzyme synthesis; epimerization; hidden Markov model; molecular evolution; nonhuman; nonribosomal peptide synthesis; peptide analysis; phylogeny; polymerization; protein domain; protein motif; statistical model; amino acid sequence; bacterial genome; bacterium; classification; enzyme specificity; gene expression regulation; genetics; protein tertiary structure; sequence alignment; Amino Acid Motifs; Amino Acid Sequence; Bacteria; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genome, Bacterial; Peptide Synthases; Phylogeny; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/177993
• Institution: National University of Singapore

10.1186/1471-2148-7-78