Nrf2 is a central regulator of metabolic reprogramming of myeloid-derived suppressor cells in steady state and sepsis

• Main Authors: Ohl, K, Fragoulis, A, Klemm, P, Baumeister, J, Klock, W, Verjans, E, Böll, S, Möllmann, J, Lehrke, M, Costa, I, Denecke, B, Schippers, A, Roth, J, Wagner, N, Wruck, C, Tenbrock, K
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: 2020
• Subjects: CD11b antigen; CD4 antigen; complementary DNA; deoxyribonuclease I; granulocyte macrophage colony stimulating factor; inducible nitric oxide synthase; interleukin 1; interleukin 12; interleukin 6; kelch like ECH associated protein 1; toll like receptor 4; transcription factor Nrf2; transcriptome; uracil DNA glycosidase; aerobic glycolysis; animal cell; animal experiment; animal model; animal tissue; Article; CD4+ T lymphocyte; cell cycle; cell expansion; colitis; controlled study; gene expression; immunological tolerance; immunomodulation; in vitro study; in vivo study; lipopolysaccharide-induced sepsis; metabolic activation; metabolic regulation; mitochondrial respiration; mouse; myeloid-derived suppressor cell; nonhuman; nuclear reprogramming; oxidative stress; transcriptomics
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178079
• Institution: National University of Singapore

10.3389/fimmu.2018.01552