An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

10.1186/s12977-018-0407-4

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Main Authors:	Ingemarsdotter, C.K, Zeng, J, Long, Z, Lever, A.M.L, Kenyon, J.C
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	4 [(1 methyl 6 nitro 4(1h) quinolinylidene)amino] n [4 [(1 methyl 4(1h) pyridinylidene)amino]phenyl]benzamide antiretrovirus agent Gag protein genomic RNA nsc 260594 unclassified drug virus RNA protein binding 5' untranslated region Article conformational transition controlled study cytoplasm dimerization enzyme linked immunosorbent assay Human immunodeficiency virus 1 nonhuman reverse transcription polymerase chain reaction RNA encapsidation RNA structure virion virus DNA cell DNA interaction virus entry virus infectivity virus particle Western blotting chemistry conformation genetics genomic instability human Human immunodeficiency virus infection metabolism physiology provirus real time polymerase chain reaction virology virus assembly virus genome virus load virus release 5' Untranslated Regions Gene Products, gag Genome, Viral Genomic Instability HIV Infections HIV-1 Humans Nucleic Acid Conformation Protein Binding Proviruses Real-Time Polymerase Chain Reaction RNA, Viral Viral Load Virus Assembly Virus Integration Virus Release
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178100
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1781002024-04-18T03:08:49Z An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation Ingemarsdotter, C.K Zeng, J Long, Z Lever, A.M.L Kenyon, J.C MEDICINE MICROBIOLOGY AND IMMUNOLOGY 4 [(1 methyl 6 nitro 4(1h) quinolinylidene)amino] n [4 [(1 methyl 4(1h) pyridinylidene)amino]phenyl]benzamide antiretrovirus agent Gag protein genomic RNA nsc 260594 unclassified drug virus RNA protein binding 5' untranslated region Article conformational transition controlled study cytoplasm dimerization enzyme linked immunosorbent assay Human immunodeficiency virus 1 nonhuman reverse transcription polymerase chain reaction RNA encapsidation RNA structure virion virus DNA cell DNA interaction virus entry virus infectivity virus particle Western blotting chemistry conformation genetics genomic instability human Human immunodeficiency virus 1 Human immunodeficiency virus infection metabolism physiology provirus real time polymerase chain reaction virology virus assembly virus genome virus load virus release 5' Untranslated Regions Gene Products, gag Genome, Viral Genomic Instability HIV Infections HIV-1 Humans Nucleic Acid Conformation Protein Binding Proviruses Real-Time Polymerase Chain Reaction RNA, Viral Viral Load Virus Assembly Virus Integration Virus Release 10.1186/s12977-018-0407-4 Retrovirology 15 1 25 2020-10-20T05:05:57Z 2020-10-20T05:05:57Z 2018 Article Ingemarsdotter, C.K, Zeng, J, Long, Z, Lever, A.M.L, Kenyon, J.C (2018). An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation. Retrovirology 15 (1) : 25. ScholarBank@NUS Repository. https://doi.org/10.1186/s12977-018-0407-4 17424690 https://scholarbank.nus.edu.sg/handle/10635/178100 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	4 [(1 methyl 6 nitro 4(1h) quinolinylidene)amino] n [4 [(1 methyl 4(1h) pyridinylidene)amino]phenyl]benzamide antiretrovirus agent Gag protein genomic RNA nsc 260594 unclassified drug virus RNA protein binding 5' untranslated region Article conformational transition controlled study cytoplasm dimerization enzyme linked immunosorbent assay Human immunodeficiency virus 1 nonhuman reverse transcription polymerase chain reaction RNA encapsidation RNA structure virion virus DNA cell DNA interaction virus entry virus infectivity virus particle Western blotting chemistry conformation genetics genomic instability human Human immunodeficiency virus 1 Human immunodeficiency virus infection metabolism physiology provirus real time polymerase chain reaction virology virus assembly virus genome virus load virus release 5' Untranslated Regions Gene Products, gag Genome, Viral Genomic Instability HIV Infections HIV-1 Humans Nucleic Acid Conformation Protein Binding Proviruses Real-Time Polymerase Chain Reaction RNA, Viral Viral Load Virus Assembly Virus Integration Virus Release
spellingShingle	4 [(1 methyl 6 nitro 4(1h) quinolinylidene)amino] n [4 [(1 methyl 4(1h) pyridinylidene)amino]phenyl]benzamide antiretrovirus agent Gag protein genomic RNA nsc 260594 unclassified drug virus RNA protein binding 5' untranslated region Article conformational transition controlled study cytoplasm dimerization enzyme linked immunosorbent assay Human immunodeficiency virus 1 nonhuman reverse transcription polymerase chain reaction RNA encapsidation RNA structure virion virus DNA cell DNA interaction virus entry virus infectivity virus particle Western blotting chemistry conformation genetics genomic instability human Human immunodeficiency virus 1 Human immunodeficiency virus infection metabolism physiology provirus real time polymerase chain reaction virology virus assembly virus genome virus load virus release 5' Untranslated Regions Gene Products, gag Genome, Viral Genomic Instability HIV Infections HIV-1 Humans Nucleic Acid Conformation Protein Binding Proviruses Real-Time Polymerase Chain Reaction RNA, Viral Viral Load Virus Assembly Virus Integration Virus Release Ingemarsdotter, C.K Zeng, J Long, Z Lever, A.M.L Kenyon, J.C An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation
description	10.1186/s12977-018-0407-4
author2	MEDICINE
author_facet	MEDICINE Ingemarsdotter, C.K Zeng, J Long, Z Lever, A.M.L Kenyon, J.C
format	Article
author	Ingemarsdotter, C.K Zeng, J Long, Z Lever, A.M.L Kenyon, J.C
author_sort	Ingemarsdotter, C.K
title	An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation
title_short	An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation
title_full	An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation
title_fullStr	An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation
title_full_unstemmed	An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation
title_sort	rna-binding compound that stabilizes the hiv-1 grna packaging signal structure and specifically blocks hiv-1 rna encapsidation
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178100
_version_	1800914476402212864

An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

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