An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

• Main Authors: Ingemarsdotter, C.K, Zeng, J, Long, Z, Lever, A.M.L, Kenyon, J.C
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: 4 [(1 methyl 6 nitro 4(1h) quinolinylidene)amino] n [4 [(1 methyl 4(1h) pyridinylidene)amino]phenyl]benzamide; antiretrovirus agent; Gag protein; genomic RNA; nsc 260594; unclassified drug; virus RNA; protein binding; 5' untranslated region; Article; conformational transition; controlled study; cytoplasm; dimerization; enzyme linked immunosorbent assay; Human immunodeficiency virus 1; nonhuman; reverse transcription polymerase chain reaction; RNA encapsidation; RNA structure; virion; virus DNA cell DNA interaction; virus entry; virus infectivity; virus particle; Western blotting; chemistry; conformation; genetics; genomic instability; human; Human immunodeficiency virus infection; metabolism; physiology; provirus; real time polymerase chain reaction; virology; virus assembly; virus genome; virus load; virus release; 5' Untranslated Regions; Gene Products, gag; Genome, Viral; Genomic Instability; HIV Infections; HIV-1; Humans; Nucleic Acid Conformation; Protein Binding; Proviruses; Real-Time Polymerase Chain Reaction; RNA, Viral; Viral Load; Virus Assembly; Virus Integration; Virus Release
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178100
• Institution: National University of Singapore

10.1186/s12977-018-0407-4