Identification of early indicators of altered metabolism in normal development using a rodent model system

• Main Authors: Prabakaran, A.D, Karakkat, J.V, Vijayan, R, Chalissery, J, Ibrahim, M.F, Kaimala, S, Adeghate, E.A, Al-Marzouqi, A.H, Ansari, S.A, Mensah-Brown, E, Emerald, B.S
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Review
• Published: 2020
• Subjects: 2 aminoadipate aminotransferase; 4 carboxyglutamic acid; adiponectin; bone sialoprotein; collagenase 3; DNA (cytosine 5) methyltransferase 1; DNA methyltransferase 3A; DNA methyltransferase 3B; endothelin 1; gelatinase B; genomic DNA; glucagon; glucose; histone deacetylase 1; insulin; leptin; messenger RNA; neutrophil collagenase; osteopontin; peroxisome proliferator activated receptor gamma; phosphatidylinositol 3 kinase; potassium channel; protein kinase B; protein p16; protein p21; protein Patched 1; retinoblastoma binding protein 1; retinoid X receptor alpha; RNA 18S; transcription factor E2F1; fatty acid; methyltransferase; animal cell; animal experiment; animal model; animal tissue; cell cycle G0 phase; cell cycle G1 phase; cell proliferation; comparative study; controlled study; DNA methylation; embryo; female; gene expression; gene identification; glucagon blood level; glucose blood level; glucose metabolism; glucose tolerance test; insulin blood level; insulin metabolism; litter size; low birth weight; male; metabolic disorder; metabolic parameters; metabolic regulation; mRNA expression level; nonhuman; nucleotide sequence; pancreas islet; Pi3K/Akt signaling; priority journal; promoter region; protein expression level; rat; repressor gene; Review; rodent model; upregulation; animal; birth weight; cell cycle; DNA microarray; gene expression profiling; gene expression regulation; genetics; growth, development and aging; metabolism; newborn; pancreas islet beta cell; real time polymerase chain reaction; secretion (process); signal transduction; skeletal muscle; Wistar rat; Animals; Animals, Newborn; Birth Weight; Cell Cycle; DNA Methylation; Fatty Acids; Gene Expression Profiling; Gene Expression Regulation, Developmental; Glucagon; Glucose; Growth and Development; Insulin; Insulin-Secreting Cells; Metabolism; Methyltransferases; Models, Animal; Muscle, Skeletal; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; PPAR gamma; Proto-Oncogene Proteins c-akt; Rats, Wistar; Real-Time Polymerase Chain Reaction; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178102
• Institution: National University of Singapore

10.1242/dmm.031815