Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells

10.1186/s13073-017-0511-4

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Main Authors:	Kundu, S, Ali, M.A, Handin, N, Padhan, N, Larsson, J, Karoutsou, M, Ban, K, Wisniewski, J.R, Artursson, P, He, L, Hellström, M, Sjöblom, T
Other Authors:	DEPT OF BIOCHEMISTRY
Format:	Article
Published:	2020
Subjects:	cetuximab epidermal growth factor receptor glucose glucose transporter 1 mitogen activated protein kinase mitogen activated protein kinase kinase Ras protein transcription factor 7 like 2 transcription factor FKHRL1 FOXO3 protein, human NCOA3 protein, human SLC2A1 protein, human small interfering RNA steroid receptor coactivator 3 TCF7L2 protein, human anchorage independent growth Article cancer growth colorectal cancer cell line controlled study drug sensitivity enzyme phosphorylation FOXO3 gene gene gene expression gene knockdown gene sequence genetic screening GLUT1 gene mutagenesis NCOA3 gene oncogene K ras phenotype priority journal TCF7L2 gene transposon wild type cell proliferation colorectal tumor drug effect drug resistance gene expression regulation genetics human human genome metabolism pathology phosphorylation proteomics signal transduction tumor cell line Cell Line, Tumor Cell Proliferation Cetuximab Colorectal Neoplasms DNA Transposable Elements Drug Resistance, Neoplasm Extracellular Signal-Regulated MAP Kinases Forkhead Box Protein O3 Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic Testing Genome, Human Glucose Transporter Type 1 Humans Nuclear Receptor Coactivator 3 Phenotype Phosphorylation Proteomics ras Proteins RNA, Small Interfering Signal Transduction Transcription Factor 7-Like 2 Protein
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178120
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1781202023-10-31T09:23:00Z Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells Kundu, S Ali, M.A Handin, N Padhan, N Larsson, J Karoutsou, M Ban, K Wisniewski, J.R Artursson, P He, L Hellström, M Sjöblom, T DEPT OF BIOCHEMISTRY cetuximab epidermal growth factor receptor glucose glucose transporter 1 mitogen activated protein kinase mitogen activated protein kinase kinase Ras protein transcription factor 7 like 2 transcription factor FKHRL1 cetuximab FOXO3 protein, human glucose transporter 1 mitogen activated protein kinase NCOA3 protein, human Ras protein SLC2A1 protein, human small interfering RNA steroid receptor coactivator 3 TCF7L2 protein, human transcription factor 7 like 2 transcription factor FKHRL1 anchorage independent growth Article cancer growth colorectal cancer cell line controlled study drug sensitivity enzyme phosphorylation FOXO3 gene gene gene expression gene knockdown gene sequence genetic screening GLUT1 gene mutagenesis NCOA3 gene oncogene K ras phenotype priority journal TCF7L2 gene transposon wild type cell proliferation colorectal tumor drug effect drug resistance gene expression regulation genetic screening genetics human human genome metabolism pathology phenotype phosphorylation proteomics signal transduction tumor cell line Cell Line, Tumor Cell Proliferation Cetuximab Colorectal Neoplasms DNA Transposable Elements Drug Resistance, Neoplasm Extracellular Signal-Regulated MAP Kinases Forkhead Box Protein O3 Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic Testing Genome, Human Glucose Transporter Type 1 Humans Nuclear Receptor Coactivator 3 Phenotype Phosphorylation Proteomics ras Proteins RNA, Small Interfering Signal Transduction Transcription Factor 7-Like 2 Protein 10.1186/s13073-017-0511-4 Genome Medicine 10 1 2 2020-10-20T05:10:31Z 2020-10-20T05:10:31Z 2018 Article Kundu, S, Ali, M.A, Handin, N, Padhan, N, Larsson, J, Karoutsou, M, Ban, K, Wisniewski, J.R, Artursson, P, He, L, Hellström, M, Sjöblom, T (2018). Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells. Genome Medicine 10 (1) : 2. ScholarBank@NUS Repository. https://doi.org/10.1186/s13073-017-0511-4 1756994X https://scholarbank.nus.edu.sg/handle/10635/178120 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	cetuximab epidermal growth factor receptor glucose glucose transporter 1 mitogen activated protein kinase mitogen activated protein kinase kinase Ras protein transcription factor 7 like 2 transcription factor FKHRL1 cetuximab FOXO3 protein, human glucose transporter 1 mitogen activated protein kinase NCOA3 protein, human Ras protein SLC2A1 protein, human small interfering RNA steroid receptor coactivator 3 TCF7L2 protein, human transcription factor 7 like 2 transcription factor FKHRL1 anchorage independent growth Article cancer growth colorectal cancer cell line controlled study drug sensitivity enzyme phosphorylation FOXO3 gene gene gene expression gene knockdown gene sequence genetic screening GLUT1 gene mutagenesis NCOA3 gene oncogene K ras phenotype priority journal TCF7L2 gene transposon wild type cell proliferation colorectal tumor drug effect drug resistance gene expression regulation genetic screening genetics human human genome metabolism pathology phenotype phosphorylation proteomics signal transduction tumor cell line Cell Line, Tumor Cell Proliferation Cetuximab Colorectal Neoplasms DNA Transposable Elements Drug Resistance, Neoplasm Extracellular Signal-Regulated MAP Kinases Forkhead Box Protein O3 Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic Testing Genome, Human Glucose Transporter Type 1 Humans Nuclear Receptor Coactivator 3 Phenotype Phosphorylation Proteomics ras Proteins RNA, Small Interfering Signal Transduction Transcription Factor 7-Like 2 Protein
spellingShingle	cetuximab epidermal growth factor receptor glucose glucose transporter 1 mitogen activated protein kinase mitogen activated protein kinase kinase Ras protein transcription factor 7 like 2 transcription factor FKHRL1 cetuximab FOXO3 protein, human glucose transporter 1 mitogen activated protein kinase NCOA3 protein, human Ras protein SLC2A1 protein, human small interfering RNA steroid receptor coactivator 3 TCF7L2 protein, human transcription factor 7 like 2 transcription factor FKHRL1 anchorage independent growth Article cancer growth colorectal cancer cell line controlled study drug sensitivity enzyme phosphorylation FOXO3 gene gene gene expression gene knockdown gene sequence genetic screening GLUT1 gene mutagenesis NCOA3 gene oncogene K ras phenotype priority journal TCF7L2 gene transposon wild type cell proliferation colorectal tumor drug effect drug resistance gene expression regulation genetic screening genetics human human genome metabolism pathology phenotype phosphorylation proteomics signal transduction tumor cell line Cell Line, Tumor Cell Proliferation Cetuximab Colorectal Neoplasms DNA Transposable Elements Drug Resistance, Neoplasm Extracellular Signal-Regulated MAP Kinases Forkhead Box Protein O3 Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic Testing Genome, Human Glucose Transporter Type 1 Humans Nuclear Receptor Coactivator 3 Phenotype Phosphorylation Proteomics ras Proteins RNA, Small Interfering Signal Transduction Transcription Factor 7-Like 2 Protein Kundu, S Ali, M.A Handin, N Padhan, N Larsson, J Karoutsou, M Ban, K Wisniewski, J.R Artursson, P He, L Hellström, M Sjöblom, T Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells
description	10.1186/s13073-017-0511-4
author2	DEPT OF BIOCHEMISTRY
author_facet	DEPT OF BIOCHEMISTRY Kundu, S Ali, M.A Handin, N Padhan, N Larsson, J Karoutsou, M Ban, K Wisniewski, J.R Artursson, P He, L Hellström, M Sjöblom, T
format	Article
author	Kundu, S Ali, M.A Handin, N Padhan, N Larsson, J Karoutsou, M Ban, K Wisniewski, J.R Artursson, P He, L Hellström, M Sjöblom, T
author_sort	Kundu, S
title	Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells
title_short	Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells
title_full	Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells
title_fullStr	Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells
title_full_unstemmed	Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells
title_sort	linking foxo3, ncoa3, and tcf7l2 to ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178120
_version_	1781792286610292736

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells

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