Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells

• Main Authors: Kundu, S, Ali, M.A, Handin, N, Padhan, N, Larsson, J, Karoutsou, M, Ban, K, Wisniewski, J.R, Artursson, P, He, L, Hellström, M, Sjöblom, T
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: cetuximab; epidermal growth factor receptor; glucose; glucose transporter 1; mitogen activated protein kinase; mitogen activated protein kinase kinase; Ras protein; transcription factor 7 like 2; transcription factor FKHRL1; FOXO3 protein, human; NCOA3 protein, human; SLC2A1 protein, human; small interfering RNA; steroid receptor coactivator 3; TCF7L2 protein, human; anchorage independent growth; Article; cancer growth; colorectal cancer cell line; controlled study; drug sensitivity; enzyme phosphorylation; FOXO3 gene; gene; gene expression; gene knockdown; gene sequence; genetic screening; GLUT1 gene; mutagenesis; NCOA3 gene; oncogene K ras; phenotype; priority journal; TCF7L2 gene; transposon; wild type; cell proliferation; colorectal tumor; drug effect; drug resistance; gene expression regulation; genetics; human; human genome; metabolism; pathology; phosphorylation; proteomics; signal transduction; tumor cell line; Cell Line, Tumor; Cell Proliferation; Cetuximab; Colorectal Neoplasms; DNA Transposable Elements; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genetic Testing; Genome, Human; Glucose Transporter Type 1; Humans; Nuclear Receptor Coactivator 3; Phenotype; Phosphorylation; Proteomics; ras Proteins; RNA, Small Interfering; Signal Transduction; Transcription Factor 7-Like 2 Protein
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178120
• Institution: National University of Singapore

10.1186/s13073-017-0511-4