Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

10.1186/1742-2094-9-62

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Main Authors:	Ferretti, M.T, Allard, S, Partridge, V, Ducatenzeiler, A, Cuello, A.C
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	BMC 2020
Subjects:	amyloid precursor protein beta secretase 1 cyclooxygenase 2 immunoglobulin enhancer binding protein inducible nitric oxide synthase m 9511 minocycline placebo unclassified drug actin binding protein Aif1 protein, mouse amyloid beta protein amyloid beta protein (1 42) amyloid beta protein[1-40] amyloid beta-protein (1-42) aspartic proteinase Bace1 protein, mouse calcium binding protein CTF 1 transcription factor CTF-1 transcription factor interleukin 1beta nuclear factor I peptide fragment Ptgs2 protein, mouse secretase Alzheimer disease amyloid plaque animal cell animal experiment animal model animal tissue antiinflammatory activity article controlled study down regulation drug effect drug mechanism enzyme activity enzyme induction female male mouse nervous system inflammation nonhuman transgenic mouse amyloid neuropathy analysis of variance animal C57BL mouse disease model enzyme linked immunosorbent assay genetics human metabolism mutation neurogenic inflammation newborn Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Neuropathies Amyloid Precursor Protein Secretases Analysis of Variance Animals Animals, Newborn Aspartic Acid Endopeptidases Calcium-Binding Proteins Cyclooxygenase 2 Disease Models, Animal Down-Regulation Enzyme-Linked Immunosorbent Assay Humans Interleukin-1beta Mice Mice, Inbred C57BL Mice, Transgenic Microfilament Proteins Minocycline Mutation Neurogenic Inflammation NFI Transcription Factors Nitric Oxide Synthase Type II Peptide Fragments
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178149
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1781492023-09-05T21:57:39Z Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology Ferretti, M.T Allard, S Partridge, V Ducatenzeiler, A Cuello, A.C DEPT OF PHARMACOLOGY amyloid precursor protein beta secretase 1 cyclooxygenase 2 immunoglobulin enhancer binding protein inducible nitric oxide synthase m 9511 minocycline placebo unclassified drug actin binding protein Aif1 protein, mouse amyloid beta protein amyloid beta protein (1 42) amyloid beta protein[1-40] amyloid beta-protein (1-42) amyloid precursor protein aspartic proteinase Bace1 protein, mouse calcium binding protein CTF 1 transcription factor CTF-1 transcription factor cyclooxygenase 2 inducible nitric oxide synthase interleukin 1beta minocycline nuclear factor I peptide fragment Ptgs2 protein, mouse secretase Alzheimer disease amyloid plaque animal cell animal experiment animal model animal tissue antiinflammatory activity article controlled study down regulation drug effect drug mechanism enzyme activity enzyme induction female male mouse nervous system inflammation nonhuman transgenic mouse Alzheimer disease amyloid neuropathy analysis of variance animal C57BL mouse disease model down regulation enzyme linked immunosorbent assay genetics human metabolism mutation neurogenic inflammation newborn Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Neuropathies Amyloid Precursor Protein Secretases Analysis of Variance Animals Animals, Newborn Aspartic Acid Endopeptidases Calcium-Binding Proteins Cyclooxygenase 2 Disease Models, Animal Down-Regulation Enzyme-Linked Immunosorbent Assay Humans Interleukin-1beta Mice Mice, Inbred C57BL Mice, Transgenic Microfilament Proteins Minocycline Mutation Neurogenic Inflammation NFI Transcription Factors Nitric Oxide Synthase Type II Peptide Fragments 10.1186/1742-2094-9-62 Journal of Neuroinflammation 9 62 2020-10-20T08:06:56Z 2020-10-20T08:06:56Z 2012 Article Ferretti, M.T, Allard, S, Partridge, V, Ducatenzeiler, A, Cuello, A.C (2012). Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology. Journal of Neuroinflammation 9 : 62. ScholarBank@NUS Repository. https://doi.org/10.1186/1742-2094-9-62 1742-2094 https://scholarbank.nus.edu.sg/handle/10635/178149 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ BMC Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	amyloid precursor protein beta secretase 1 cyclooxygenase 2 immunoglobulin enhancer binding protein inducible nitric oxide synthase m 9511 minocycline placebo unclassified drug actin binding protein Aif1 protein, mouse amyloid beta protein amyloid beta protein (1 42) amyloid beta protein[1-40] amyloid beta-protein (1-42) amyloid precursor protein aspartic proteinase Bace1 protein, mouse calcium binding protein CTF 1 transcription factor CTF-1 transcription factor cyclooxygenase 2 inducible nitric oxide synthase interleukin 1beta minocycline nuclear factor I peptide fragment Ptgs2 protein, mouse secretase Alzheimer disease amyloid plaque animal cell animal experiment animal model animal tissue antiinflammatory activity article controlled study down regulation drug effect drug mechanism enzyme activity enzyme induction female male mouse nervous system inflammation nonhuman transgenic mouse Alzheimer disease amyloid neuropathy analysis of variance animal C57BL mouse disease model down regulation enzyme linked immunosorbent assay genetics human metabolism mutation neurogenic inflammation newborn Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Neuropathies Amyloid Precursor Protein Secretases Analysis of Variance Animals Animals, Newborn Aspartic Acid Endopeptidases Calcium-Binding Proteins Cyclooxygenase 2 Disease Models, Animal Down-Regulation Enzyme-Linked Immunosorbent Assay Humans Interleukin-1beta Mice Mice, Inbred C57BL Mice, Transgenic Microfilament Proteins Minocycline Mutation Neurogenic Inflammation NFI Transcription Factors Nitric Oxide Synthase Type II Peptide Fragments
spellingShingle	amyloid precursor protein beta secretase 1 cyclooxygenase 2 immunoglobulin enhancer binding protein inducible nitric oxide synthase m 9511 minocycline placebo unclassified drug actin binding protein Aif1 protein, mouse amyloid beta protein amyloid beta protein (1 42) amyloid beta protein[1-40] amyloid beta-protein (1-42) amyloid precursor protein aspartic proteinase Bace1 protein, mouse calcium binding protein CTF 1 transcription factor CTF-1 transcription factor cyclooxygenase 2 inducible nitric oxide synthase interleukin 1beta minocycline nuclear factor I peptide fragment Ptgs2 protein, mouse secretase Alzheimer disease amyloid plaque animal cell animal experiment animal model animal tissue antiinflammatory activity article controlled study down regulation drug effect drug mechanism enzyme activity enzyme induction female male mouse nervous system inflammation nonhuman transgenic mouse Alzheimer disease amyloid neuropathy analysis of variance animal C57BL mouse disease model down regulation enzyme linked immunosorbent assay genetics human metabolism mutation neurogenic inflammation newborn Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Neuropathies Amyloid Precursor Protein Secretases Analysis of Variance Animals Animals, Newborn Aspartic Acid Endopeptidases Calcium-Binding Proteins Cyclooxygenase 2 Disease Models, Animal Down-Regulation Enzyme-Linked Immunosorbent Assay Humans Interleukin-1beta Mice Mice, Inbred C57BL Mice, Transgenic Microfilament Proteins Minocycline Mutation Neurogenic Inflammation NFI Transcription Factors Nitric Oxide Synthase Type II Peptide Fragments Ferretti, M.T Allard, S Partridge, V Ducatenzeiler, A Cuello, A.C Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
description	10.1186/1742-2094-9-62
author2	DEPT OF PHARMACOLOGY
author_facet	DEPT OF PHARMACOLOGY Ferretti, M.T Allard, S Partridge, V Ducatenzeiler, A Cuello, A.C
format	Article
author	Ferretti, M.T Allard, S Partridge, V Ducatenzeiler, A Cuello, A.C
author_sort	Ferretti, M.T
title	Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
title_short	Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
title_full	Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
title_fullStr	Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
title_full_unstemmed	Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
title_sort	minocycline corrects early, pre-plaque neuroinflammation and inhibits bace-1 in a transgenic model of alzheimer's disease-like amyloid pathology
publisher	BMC
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178149
_version_	1779152179718782976

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

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