Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

10.1186/1742-2094-9-62

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Bibliographic Details
Main Authors:	Ferretti, M.T, Allard, S, Partridge, V, Ducatenzeiler, A, Cuello, A.C
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	BMC 2020
Subjects:	amyloid precursor protein beta secretase 1 cyclooxygenase 2 immunoglobulin enhancer binding protein inducible nitric oxide synthase m 9511 minocycline placebo unclassified drug actin binding protein Aif1 protein, mouse amyloid beta protein amyloid beta protein (1 42) amyloid beta protein[1-40] amyloid beta-protein (1-42) aspartic proteinase Bace1 protein, mouse calcium binding protein CTF 1 transcription factor CTF-1 transcription factor interleukin 1beta nuclear factor I peptide fragment Ptgs2 protein, mouse secretase Alzheimer disease amyloid plaque animal cell animal experiment animal model animal tissue antiinflammatory activity article controlled study down regulation drug effect drug mechanism enzyme activity enzyme induction female male mouse nervous system inflammation nonhuman transgenic mouse amyloid neuropathy analysis of variance animal C57BL mouse disease model enzyme linked immunosorbent assay genetics human metabolism mutation neurogenic inflammation newborn Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Neuropathies Amyloid Precursor Protein Secretases Analysis of Variance Animals Animals, Newborn Aspartic Acid Endopeptidases Calcium-Binding Proteins Cyclooxygenase 2 Disease Models, Animal Down-Regulation Enzyme-Linked Immunosorbent Assay Humans Interleukin-1beta Mice Mice, Inbred C57BL Mice, Transgenic Microfilament Proteins Minocycline Mutation Neurogenic Inflammation NFI Transcription Factors Nitric Oxide Synthase Type II Peptide Fragments
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178149
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Institution:	National University of Singapore

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