Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNF?, NF?B, p38 and caspase 8 dependent pathways

• Main Authors: Green, J.A, Dholakia, S, Janczar, K, Ong, C.W.M, Moores, R, Fry, J, Elkington, P.T, Roncaroli, F, Friedland, J.S
• Other Authors: MEDICINE
• Format: Article
• Published: BMC 2020
• Subjects: caspase 8; gelatinase A; immunoglobulin enhancer binding protein; mitogen activated protein kinase p38; transcription factor RelA; tumor necrosis factor alpha; helenalin; mitogen activated protein kinase; nonsteroid antiinflammatory agent; sesquiterpene; article; brain biopsy; central nervous system tuberculosis; clinical article; controlled study; down regulation; enzyme inhibition; enzyme regulation; enzyme release; gene expression; human; human cell; human tissue; macrophage; microglia; monocyte; Mycobacterium tuberculosis; nonhuman; chemistry; culture medium; cytology; genetics; metabolism; microbiology; pathogenicity; physiology; secretion; signal transduction; Anti-Inflammatory Agents, Non-Steroidal; Caspase 8; Culture Media, Conditioned; Extracellular Signal-Regulated MAP Kinases; Humans; Matrix Metalloproteinase 2; Microglia; Monocytes; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Sesquiterpenes; Signal Transduction; Tuberculosis, Central Nervous System; Tumor Necrosis Factor-alpha
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178177
• Institution: National University of Singapore

10.1186/1742-2094-8-46