Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors

Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors

10.3390/cancers9080109

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Bibliographic Details
Main Authors:	Lim, J.S.J, Tan, D.S.P
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Review
Published:	2020
Subjects:	double stranded DNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor niraparib olaparib rucaparib talazoparib veliparib acute myeloid leukemia alopecia anemia bone marrow suppression breast cancer breast tumor cancer resistance cancer survival DNA end joining repair DNA strand breakage drug approval drug efficacy drug safety drug tolerability esophagus tumor Ewing sarcoma fatigue female genital tract tumor food and drug administration gastrointestinal toxicity gene mutation germ cell tumor human liver dysfunction lymphocytopenia lymphoma neuroendocrine tumor non small cell lung cancer nonhuman outcome assessment ovary tumor overall survival pancreas tumor progression free survival prostate tumor Review sarcoma solid malignant neoplasm somnolence thrombocytopenia tumor suppressor gene
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178338
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Institution:	National University of Singapore

Description
Summary:	10.3390/cancers9080109