Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors

10.3390/cancers9080109

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Bibliographic Details
Main Authors:	Lim, J.S.J, Tan, D.S.P
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Review
Published:	2020
Subjects:	double stranded DNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor niraparib olaparib rucaparib talazoparib veliparib acute myeloid leukemia alopecia anemia bone marrow suppression breast cancer breast tumor cancer resistance cancer survival DNA end joining repair DNA strand breakage drug approval drug efficacy drug safety drug tolerability esophagus tumor Ewing sarcoma fatigue female genital tract tumor food and drug administration gastrointestinal toxicity gene mutation germ cell tumor human liver dysfunction lymphocytopenia lymphoma neuroendocrine tumor non small cell lung cancer nonhuman outcome assessment ovary tumor overall survival pancreas tumor progression free survival prostate tumor Review sarcoma solid malignant neoplasm somnolence thrombocytopenia tumor suppressor gene
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178338
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-178338
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spelling	sg-nus-scholar.10635-1783382024-04-18T03:06:56Z Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors Lim, J.S.J Tan, D.S.P CANCER SCIENCE INSTITUTE OF SINGAPORE MEDICINE double stranded DNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor niraparib olaparib rucaparib talazoparib veliparib acute myeloid leukemia alopecia anemia bone marrow suppression breast cancer breast tumor cancer resistance cancer survival DNA end joining repair DNA strand breakage drug approval drug efficacy drug safety drug tolerability esophagus tumor Ewing sarcoma fatigue female genital tract tumor food and drug administration gastrointestinal toxicity gene mutation germ cell tumor human liver dysfunction lymphocytopenia lymphoma neuroendocrine tumor non small cell lung cancer nonhuman outcome assessment ovary tumor overall survival pancreas tumor progression free survival prostate tumor Review sarcoma solid malignant neoplasm somnolence thrombocytopenia tumor suppressor gene 10.3390/cancers9080109 Cancers 9 8 109 2020-10-20T09:17:02Z 2020-10-20T09:17:02Z 2017 Review Lim, J.S.J, Tan, D.S.P (2017). Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors. Cancers 9 (8) : 109. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers9080109 20726694 https://scholarbank.nus.edu.sg/handle/10635/178338 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	double stranded DNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor niraparib olaparib rucaparib talazoparib veliparib acute myeloid leukemia alopecia anemia bone marrow suppression breast cancer breast tumor cancer resistance cancer survival DNA end joining repair DNA strand breakage drug approval drug efficacy drug safety drug tolerability esophagus tumor Ewing sarcoma fatigue female genital tract tumor food and drug administration gastrointestinal toxicity gene mutation germ cell tumor human liver dysfunction lymphocytopenia lymphoma neuroendocrine tumor non small cell lung cancer nonhuman outcome assessment ovary tumor overall survival pancreas tumor progression free survival prostate tumor Review sarcoma solid malignant neoplasm somnolence thrombocytopenia tumor suppressor gene
spellingShingle	double stranded DNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor niraparib olaparib rucaparib talazoparib veliparib acute myeloid leukemia alopecia anemia bone marrow suppression breast cancer breast tumor cancer resistance cancer survival DNA end joining repair DNA strand breakage drug approval drug efficacy drug safety drug tolerability esophagus tumor Ewing sarcoma fatigue female genital tract tumor food and drug administration gastrointestinal toxicity gene mutation germ cell tumor human liver dysfunction lymphocytopenia lymphoma neuroendocrine tumor non small cell lung cancer nonhuman outcome assessment ovary tumor overall survival pancreas tumor progression free survival prostate tumor Review sarcoma solid malignant neoplasm somnolence thrombocytopenia tumor suppressor gene Lim, J.S.J Tan, D.S.P Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors
description	10.3390/cancers9080109
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Lim, J.S.J Tan, D.S.P
format	Review
author	Lim, J.S.J Tan, D.S.P
author_sort	Lim, J.S.J
title	Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors
title_short	Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors
title_full	Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors
title_fullStr	Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors
title_full_unstemmed	Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors
title_sort	understanding resistance mechanisms and expanding the therapeutic utility of parp inhibitors
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178338
_version_	1800914491212300288

Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors

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