Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage

• Main Authors: Strappe, P.M, Hampton, D.W, Bown, D, Gonzalez, B.-C, Caldwell, M, Fawcett, J.W, Lever, A.M.L
• Other Authors: MEDICINE
• Format: Article
• Published: BMC 2020
• Subjects: Gag protein; lentivirus vector; Pol protein; RNA; virus RNA; animal cell; article; biosafety; cell division; central nervous system; controlled study; drug packaging; gene construct; gene transfer; genetic transduction; glia cell; human; human cell; Human immunodeficiency virus 1; Human immunodeficiency virus 2; in vivo study; nerve cell culture; neural stem cell; nonhuman; protein expression; rat; sequence homology; Simian immunodeficiency virus; target cell; viral gene delivery system; animal; astrocyte; cell line; gene vector; genetics; horizontal gene transfer; physiology; stem cell; virology; virus assembly; Animalia; Lentivirus; Animals; Astrocytes; Cell Line; Gene Transfer, Horizontal; Genetic Vectors; HIV-1; HIV-2; Humans; Rats; RNA, Viral; Stem Cells; Transduction, Genetic; Virus Assembly
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178366
• Institution: National University of Singapore

10.1186/1742-4690-2-55