Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy
10.1038/s41467-018-07261-3
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2020
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sg-nus-scholar.10635-1783802023-08-29T09:15:17Z Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy Sharma, A Cao, E.Y Kumar, V Zhang, X Leong, H.S Wong, A.M.L Ramakrishnan, N Hakimullah, M Teo, H.M.V Chong, F.T Chia, S Thangavelu, M.T Kwang, X.L Gupta, R Clark, J.R Periyasamy, G Iyer, N.G DasGupta, R DUKE-NUS MEDICAL SCHOOL 4 (4 chlorophenyl) 2,3,9 trimethyl 6h thieno[3,2 f][1,2,4]triazolo[4,3 a][1,4]diazepine 6 acetic acid tert butyl ester cisplatin cytokeratin 18 cytokeratin 8 epithelial cell adhesion molecule histone H3 RNA transcription factor Sox2 transcription factor Sox9 uvomorulin vimentin antineoplastic agent cisplatin adaptation animal experiment animal model Article cancer chemotherapy cancer resistance cell plasticity cell proliferation chromatin controlled study head and neck squamous cell carcinoma histone acetylation human human cell mouse nonhuman phenotype primary cell RNA sequence single cell analysis stem cell transcriptomics tumor xenograft animal cancer stem cell drug resistance drug screening gene expression profiling gene expression regulation genetic heterogeneity genetics knockout mouse metabolism mouth tumor nonobese diabetic mouse procedures SCID mouse sequence analysis single cell analysis squamous cell carcinoma tumor cell line Animals Antineoplastic Agents Carcinoma, Squamous Cell Cell Line, Tumor Cisplatin Drug Resistance, Neoplasm Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic Heterogeneity Humans Mice, Inbred NOD Mice, Knockout Mice, SCID Mouth Neoplasms Neoplastic Stem Cells Sequence Analysis, RNA Single-Cell Analysis Xenograft Model Antitumor Assays 10.1038/s41467-018-07261-3 Nature Communications 9 1 4931 2020-10-20T09:37:47Z 2020-10-20T09:37:47Z 2018 Article Sharma, A, Cao, E.Y, Kumar, V, Zhang, X, Leong, H.S, Wong, A.M.L, Ramakrishnan, N, Hakimullah, M, Teo, H.M.V, Chong, F.T, Chia, S, Thangavelu, M.T, Kwang, X.L, Gupta, R, Clark, J.R, Periyasamy, G, Iyer, N.G, DasGupta, R (2018). Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy. Nature Communications 9 (1) : 4931. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-07261-3 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178380 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031 |
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4 (4 chlorophenyl) 2,3,9 trimethyl 6h thieno[3,2 f][1,2,4]triazolo[4,3 a][1,4]diazepine 6 acetic acid tert butyl ester cisplatin cytokeratin 18 cytokeratin 8 epithelial cell adhesion molecule histone H3 RNA transcription factor Sox2 transcription factor Sox9 uvomorulin vimentin antineoplastic agent cisplatin adaptation animal experiment animal model Article cancer chemotherapy cancer resistance cell plasticity cell proliferation chromatin controlled study head and neck squamous cell carcinoma histone acetylation human human cell mouse nonhuman phenotype primary cell RNA sequence single cell analysis stem cell transcriptomics tumor xenograft animal cancer stem cell drug resistance drug screening gene expression profiling gene expression regulation genetic heterogeneity genetics knockout mouse metabolism mouth tumor nonobese diabetic mouse procedures SCID mouse sequence analysis single cell analysis squamous cell carcinoma tumor cell line Animals Antineoplastic Agents Carcinoma, Squamous Cell Cell Line, Tumor Cisplatin Drug Resistance, Neoplasm Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic Heterogeneity Humans Mice, Inbred NOD Mice, Knockout Mice, SCID Mouth Neoplasms Neoplastic Stem Cells Sequence Analysis, RNA Single-Cell Analysis Xenograft Model Antitumor Assays |
| spellingShingle |
4 (4 chlorophenyl) 2,3,9 trimethyl 6h thieno[3,2 f][1,2,4]triazolo[4,3 a][1,4]diazepine 6 acetic acid tert butyl ester cisplatin cytokeratin 18 cytokeratin 8 epithelial cell adhesion molecule histone H3 RNA transcription factor Sox2 transcription factor Sox9 uvomorulin vimentin antineoplastic agent cisplatin adaptation animal experiment animal model Article cancer chemotherapy cancer resistance cell plasticity cell proliferation chromatin controlled study head and neck squamous cell carcinoma histone acetylation human human cell mouse nonhuman phenotype primary cell RNA sequence single cell analysis stem cell transcriptomics tumor xenograft animal cancer stem cell drug resistance drug screening gene expression profiling gene expression regulation genetic heterogeneity genetics knockout mouse metabolism mouth tumor nonobese diabetic mouse procedures SCID mouse sequence analysis single cell analysis squamous cell carcinoma tumor cell line Animals Antineoplastic Agents Carcinoma, Squamous Cell Cell Line, Tumor Cisplatin Drug Resistance, Neoplasm Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic Heterogeneity Humans Mice, Inbred NOD Mice, Knockout Mice, SCID Mouth Neoplasms Neoplastic Stem Cells Sequence Analysis, RNA Single-Cell Analysis Xenograft Model Antitumor Assays Sharma, A Cao, E.Y Kumar, V Zhang, X Leong, H.S Wong, A.M.L Ramakrishnan, N Hakimullah, M Teo, H.M.V Chong, F.T Chia, S Thangavelu, M.T Kwang, X.L Gupta, R Clark, J.R Periyasamy, G Iyer, N.G DasGupta, R Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy |
| description |
10.1038/s41467-018-07261-3 |
| author2 |
DUKE-NUS MEDICAL SCHOOL |
| author_facet |
DUKE-NUS MEDICAL SCHOOL Sharma, A Cao, E.Y Kumar, V Zhang, X Leong, H.S Wong, A.M.L Ramakrishnan, N Hakimullah, M Teo, H.M.V Chong, F.T Chia, S Thangavelu, M.T Kwang, X.L Gupta, R Clark, J.R Periyasamy, G Iyer, N.G DasGupta, R |
| format |
Article |
| author |
Sharma, A Cao, E.Y Kumar, V Zhang, X Leong, H.S Wong, A.M.L Ramakrishnan, N Hakimullah, M Teo, H.M.V Chong, F.T Chia, S Thangavelu, M.T Kwang, X.L Gupta, R Clark, J.R Periyasamy, G Iyer, N.G DasGupta, R |
| author_sort |
Sharma, A |
| title |
Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy |
| title_short |
Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy |
| title_full |
Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy |
| title_fullStr |
Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy |
| title_full_unstemmed |
Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy |
| title_sort |
longitudinal single-cell rna sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy |
| publisher |
Nature Publishing Group |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/178380 |
| _version_ |
1779152266286071808 |