Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

• Main Authors: Than, A, Liu, C, Chang, H, Duong, P.K, Cheung, C.M.G, Xu, C, Wang, X, Chen, P
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: diclofenac; eye drops; hyaluronic acid; immunoglobulin G; interleukin 6; monoclonal antibody DC101; vasculotropin inhibitor; drug; vasculotropin A; antibody; array; eye disease; injury; reaction kinetics; animal experiment; animal model; antiangiogenic activity; Article; confocal microscopy; controlled study; cornea disease; cornea neovascularization; drug delivery system; drug megadose; drug potentiation; drug safety; drug solubility; ex vivo study; human; human tissue; male; microtechnology; molecular weight; mouse; nonhuman; pig; polyacrylamide gel electrophoresis; proof of concept; scanning electron microscopy; sustained drug release; topical treatment; treatment outcome; animal; antagonists and inhibitors; delayed release formulation; drug effect; eye; inflammation; metabolism; needle; pathology; prostheses and orthoses; Animals; Delayed-Action Preparations; Drug Delivery Systems; Eye; Inflammation; Mice; Needles; Pharmaceutical Preparations; Prostheses and Implants; Sus scrofa; Vascular Endothelial Growth Factor A
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178384
• Institution: National University of Singapore

10.1038/s41467-018-06981-w