Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

10.1038/s41467-018-06981-w

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Main Authors:	Than, A, Liu, C, Chang, H, Duong, P.K, Cheung, C.M.G, Xu, C, Wang, X, Chen, P
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	diclofenac eye drops hyaluronic acid immunoglobulin G interleukin 6 monoclonal antibody DC101 vasculotropin inhibitor drug vasculotropin A antibody array eye disease injury reaction kinetics animal experiment animal model antiangiogenic activity Article confocal microscopy controlled study cornea disease cornea neovascularization drug delivery system drug megadose drug potentiation drug safety drug solubility ex vivo study human human tissue male microtechnology molecular weight mouse nonhuman pig polyacrylamide gel electrophoresis proof of concept scanning electron microscopy sustained drug release topical treatment treatment outcome animal antagonists and inhibitors delayed release formulation drug effect eye inflammation metabolism needle pathology prostheses and orthoses Animals Delayed-Action Preparations Drug Delivery Systems Eye Inflammation Mice Needles Pharmaceutical Preparations Prostheses and Implants Sus scrofa Vascular Endothelial Growth Factor A
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178384
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1783842024-11-12T09:57:30Z Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery Than, A Liu, C Chang, H Duong, P.K Cheung, C.M.G Xu, C Wang, X Chen, P DUKE-NUS MEDICAL SCHOOL diclofenac eye drops hyaluronic acid immunoglobulin G interleukin 6 monoclonal antibody DC101 vasculotropin inhibitor drug vasculotropin A antibody array drug eye disease injury reaction kinetics animal experiment animal model antiangiogenic activity Article confocal microscopy controlled study cornea disease cornea neovascularization drug delivery system drug megadose drug potentiation drug safety drug solubility ex vivo study human human tissue male microtechnology molecular weight mouse nonhuman pig polyacrylamide gel electrophoresis proof of concept scanning electron microscopy sustained drug release topical treatment treatment outcome animal antagonists and inhibitors delayed release formulation drug effect eye inflammation metabolism needle pathology prostheses and orthoses Animals Delayed-Action Preparations Drug Delivery Systems Eye Inflammation Mice Needles Pharmaceutical Preparations Prostheses and Implants Sus scrofa Vascular Endothelial Growth Factor A 10.1038/s41467-018-06981-w Nature Communications 9 1 4433 2020-10-20T09:39:14Z 2020-10-20T09:39:14Z 2018 Article Than, A, Liu, C, Chang, H, Duong, P.K, Cheung, C.M.G, Xu, C, Wang, X, Chen, P (2018). Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nature Communications 9 (1) : 4433. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-06981-w 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178384 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	diclofenac eye drops hyaluronic acid immunoglobulin G interleukin 6 monoclonal antibody DC101 vasculotropin inhibitor drug vasculotropin A antibody array drug eye disease injury reaction kinetics animal experiment animal model antiangiogenic activity Article confocal microscopy controlled study cornea disease cornea neovascularization drug delivery system drug megadose drug potentiation drug safety drug solubility ex vivo study human human tissue male microtechnology molecular weight mouse nonhuman pig polyacrylamide gel electrophoresis proof of concept scanning electron microscopy sustained drug release topical treatment treatment outcome animal antagonists and inhibitors delayed release formulation drug effect eye inflammation metabolism needle pathology prostheses and orthoses Animals Delayed-Action Preparations Drug Delivery Systems Eye Inflammation Mice Needles Pharmaceutical Preparations Prostheses and Implants Sus scrofa Vascular Endothelial Growth Factor A
spellingShingle	diclofenac eye drops hyaluronic acid immunoglobulin G interleukin 6 monoclonal antibody DC101 vasculotropin inhibitor drug vasculotropin A antibody array drug eye disease injury reaction kinetics animal experiment animal model antiangiogenic activity Article confocal microscopy controlled study cornea disease cornea neovascularization drug delivery system drug megadose drug potentiation drug safety drug solubility ex vivo study human human tissue male microtechnology molecular weight mouse nonhuman pig polyacrylamide gel electrophoresis proof of concept scanning electron microscopy sustained drug release topical treatment treatment outcome animal antagonists and inhibitors delayed release formulation drug effect eye inflammation metabolism needle pathology prostheses and orthoses Animals Delayed-Action Preparations Drug Delivery Systems Eye Inflammation Mice Needles Pharmaceutical Preparations Prostheses and Implants Sus scrofa Vascular Endothelial Growth Factor A Than, A Liu, C Chang, H Duong, P.K Cheung, C.M.G Xu, C Wang, X Chen, P Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
description	10.1038/s41467-018-06981-w
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Than, A Liu, C Chang, H Duong, P.K Cheung, C.M.G Xu, C Wang, X Chen, P
format	Article
author	Than, A Liu, C Chang, H Duong, P.K Cheung, C.M.G Xu, C Wang, X Chen, P
author_sort	Than, A
title	Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
title_short	Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
title_full	Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
title_fullStr	Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
title_full_unstemmed	Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
title_sort	self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178384
_version_	1821225172048281600

Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

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