Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

• Main Authors: Iglesias, A.I, Mishra, A, Vitart, V, etc.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: fibroblast growth factor 1; transcription factor RUNX2; Wnt10a protein; ADAMTS protein; ADAMTS2 protein, human; DCN protein, human; decorin; FBN1 protein, human; fibrillin 1; KERA protein, human; LUM protein, human; Transforming Growth Factor beta2; lumican; proteoglycan; TGFB2 protein, human; transforming growth factor beta2; collagen; complexity; eye; genetic analysis; genome; meta-analysis; ADAMTS2 gene; ADAMTS6 gene; Article; case control study; central corneal thickness; cohort analysis; COL12A1 gene; COL4A3 gene; COL8A2 gene; connective tissue; controlled study; cornea dystrophy; Ehlers Danlos syndrome; eye disease; FAM46A gene; FBN1 gene; FNDC3B gene; gene; gene locus; genome-wide association study; human; keratoconus; Loeys Dietz syndrome; LTBP1 gene; major clinical study; Marfan syndrome; myopia; NR3C2 gene; open angle glaucoma; RABGEF1 gene; SAMD9 gene; STAG1 gene; TBL1XR1 gene; TGFB2 gene; THBS2 gene; TIPARP gene; abnormalities; Asian continental ancestry group; Caucasian; congenital cornea dystrophy; cornea; cornea disease; ethnology; gene expression; genetics; human genome; Mendelian randomization analysis; meta analysis; metabolism; pathology; quantitative trait; quantitative trait locus; single nucleotide polymorphism; ADAMTS Proteins; Asian Continental Ancestry Group; Cornea; Corneal Diseases; Corneal Dystrophies, Hereditary; Decorin; Ehlers-Danlos Syndrome; European Continental Ancestry Group; Eye Diseases, Hereditary; Fibrillin-1; Gene Expression; Genome, Human; Genome-Wide Association Study; Glaucoma, Open-Angle; Humans; Keratoconus; Loeys-Dietz Syndrome; Lumican; Marfan Syndrome; Mendelian Randomization Analysis; Myopia; Polymorphism, Single Nucleotide; Proteoglycans; Quantitative Trait Loci; Quantitative Trait, Heritable
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178412
• Institution: National University of Singapore

10.1038/s41467-018-03646-6