Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

10.1038/s41467-018-03646-6

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Main Authors:	Iglesias, A.I, Mishra, A, Vitart, V, etc.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	fibroblast growth factor 1 transcription factor RUNX2 Wnt10a protein ADAMTS protein ADAMTS2 protein, human DCN protein, human decorin FBN1 protein, human fibrillin 1 KERA protein, human LUM protein, human Transforming Growth Factor beta2 lumican proteoglycan TGFB2 protein, human transforming growth factor beta2 collagen complexity eye genetic analysis genome meta-analysis ADAMTS2 gene ADAMTS6 gene Article case control study central corneal thickness cohort analysis COL12A1 gene COL4A3 gene COL8A2 gene connective tissue controlled study cornea dystrophy Ehlers Danlos syndrome eye disease FAM46A gene FBN1 gene FNDC3B gene gene gene locus genome-wide association study human keratoconus Loeys Dietz syndrome LTBP1 gene major clinical study Marfan syndrome myopia NR3C2 gene open angle glaucoma RABGEF1 gene SAMD9 gene STAG1 gene TBL1XR1 gene TGFB2 gene THBS2 gene TIPARP gene abnormalities Asian continental ancestry group Caucasian congenital cornea dystrophy cornea cornea disease ethnology gene expression genetics human genome Mendelian randomization analysis meta analysis metabolism pathology quantitative trait quantitative trait locus single nucleotide polymorphism ADAMTS Proteins Asian Continental Ancestry Group Cornea Corneal Diseases Corneal Dystrophies, Hereditary Decorin Ehlers-Danlos Syndrome European Continental Ancestry Group Eye Diseases, Hereditary Fibrillin-1 Gene Expression Genome, Human Genome-Wide Association Study Glaucoma, Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism, Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait, Heritable
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178412
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1784122024-04-22T03:33:51Z Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases Iglesias, A.I Mishra, A Vitart, V etc. DUKE-NUS MEDICAL SCHOOL SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH BIOCHEMISTRY OPHTHALMOLOGY fibroblast growth factor 1 transcription factor RUNX2 Wnt10a protein ADAMTS protein ADAMTS2 protein, human DCN protein, human decorin FBN1 protein, human fibrillin 1 KERA protein, human LUM protein, human Transforming Growth Factor beta2 lumican proteoglycan TGFB2 protein, human transforming growth factor beta2 collagen complexity eye genetic analysis genome meta-analysis ADAMTS2 gene ADAMTS6 gene Article case control study central corneal thickness cohort analysis COL12A1 gene COL4A3 gene COL8A2 gene connective tissue controlled study cornea dystrophy Ehlers Danlos syndrome eye disease FAM46A gene FBN1 gene FNDC3B gene gene gene locus genome-wide association study human keratoconus Loeys Dietz syndrome LTBP1 gene major clinical study Marfan syndrome myopia NR3C2 gene open angle glaucoma RABGEF1 gene SAMD9 gene STAG1 gene TBL1XR1 gene TGFB2 gene THBS2 gene TIPARP gene abnormalities Asian continental ancestry group Caucasian congenital cornea dystrophy cornea cornea disease ethnology eye disease gene expression genetics human genome Mendelian randomization analysis meta analysis metabolism pathology quantitative trait quantitative trait locus single nucleotide polymorphism ADAMTS Proteins Asian Continental Ancestry Group Cornea Corneal Diseases Corneal Dystrophies, Hereditary Decorin Ehlers-Danlos Syndrome European Continental Ancestry Group Eye Diseases, Hereditary Fibrillin-1 Gene Expression Genome, Human Genome-Wide Association Study Glaucoma, Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism, Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait, Heritable 10.1038/s41467-018-03646-6 Nature Communications 9 1 1864 2020-10-20T09:49:15Z 2020-10-20T09:49:15Z 2018 Article Iglesias, A.I, Mishra, A, Vitart, V, etc. (2018). Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nature Communications 9 (1) : 1864. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-03646-6 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178412 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	fibroblast growth factor 1 transcription factor RUNX2 Wnt10a protein ADAMTS protein ADAMTS2 protein, human DCN protein, human decorin FBN1 protein, human fibrillin 1 KERA protein, human LUM protein, human Transforming Growth Factor beta2 lumican proteoglycan TGFB2 protein, human transforming growth factor beta2 collagen complexity eye genetic analysis genome meta-analysis ADAMTS2 gene ADAMTS6 gene Article case control study central corneal thickness cohort analysis COL12A1 gene COL4A3 gene COL8A2 gene connective tissue controlled study cornea dystrophy Ehlers Danlos syndrome eye disease FAM46A gene FBN1 gene FNDC3B gene gene gene locus genome-wide association study human keratoconus Loeys Dietz syndrome LTBP1 gene major clinical study Marfan syndrome myopia NR3C2 gene open angle glaucoma RABGEF1 gene SAMD9 gene STAG1 gene TBL1XR1 gene TGFB2 gene THBS2 gene TIPARP gene abnormalities Asian continental ancestry group Caucasian congenital cornea dystrophy cornea cornea disease ethnology eye disease gene expression genetics human genome Mendelian randomization analysis meta analysis metabolism pathology quantitative trait quantitative trait locus single nucleotide polymorphism ADAMTS Proteins Asian Continental Ancestry Group Cornea Corneal Diseases Corneal Dystrophies, Hereditary Decorin Ehlers-Danlos Syndrome European Continental Ancestry Group Eye Diseases, Hereditary Fibrillin-1 Gene Expression Genome, Human Genome-Wide Association Study Glaucoma, Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism, Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait, Heritable
spellingShingle	fibroblast growth factor 1 transcription factor RUNX2 Wnt10a protein ADAMTS protein ADAMTS2 protein, human DCN protein, human decorin FBN1 protein, human fibrillin 1 KERA protein, human LUM protein, human Transforming Growth Factor beta2 lumican proteoglycan TGFB2 protein, human transforming growth factor beta2 collagen complexity eye genetic analysis genome meta-analysis ADAMTS2 gene ADAMTS6 gene Article case control study central corneal thickness cohort analysis COL12A1 gene COL4A3 gene COL8A2 gene connective tissue controlled study cornea dystrophy Ehlers Danlos syndrome eye disease FAM46A gene FBN1 gene FNDC3B gene gene gene locus genome-wide association study human keratoconus Loeys Dietz syndrome LTBP1 gene major clinical study Marfan syndrome myopia NR3C2 gene open angle glaucoma RABGEF1 gene SAMD9 gene STAG1 gene TBL1XR1 gene TGFB2 gene THBS2 gene TIPARP gene abnormalities Asian continental ancestry group Caucasian congenital cornea dystrophy cornea cornea disease ethnology eye disease gene expression genetics human genome Mendelian randomization analysis meta analysis metabolism pathology quantitative trait quantitative trait locus single nucleotide polymorphism ADAMTS Proteins Asian Continental Ancestry Group Cornea Corneal Diseases Corneal Dystrophies, Hereditary Decorin Ehlers-Danlos Syndrome European Continental Ancestry Group Eye Diseases, Hereditary Fibrillin-1 Gene Expression Genome, Human Genome-Wide Association Study Glaucoma, Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism, Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait, Heritable Iglesias, A.I Mishra, A Vitart, V etc. Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
description	10.1038/s41467-018-03646-6
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Iglesias, A.I Mishra, A Vitart, V etc.
format	Article
author	Iglesias, A.I Mishra, A Vitart, V etc.
author_sort	Iglesias, A.I
title	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_short	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_full	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_fullStr	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_full_unstemmed	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_sort	cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and mendelian eye diseases
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178412
_version_	1800914497107394560

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

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