The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition

10.1038/s41598-018-25738-5

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Main Authors:	Ruiz-Carrillo, D, Lin, J, El Sahili, A, Wei, M, Sze, S.K, Cheung, P.C.F, Doerig, C, Lescar, J
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	casein kinase II protein kinase inhibitor protein tyrosine kinase amino acid sequence chemistry enzyme active site enzymology gene expression regulation genetics metabolism molecular model mutation phosphorylation Plasmodium falciparum X ray crystallography Amino Acid Sequence Casein Kinase II Catalytic Domain Crystallography, X-Ray Gene Expression Regulation, Enzymologic Models, Molecular Mutation Phosphorylation Protein Kinase Inhibitors Protein-Tyrosine Kinases
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178413
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1784132023-09-01T09:15:29Z The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition Ruiz-Carrillo, D Lin, J El Sahili, A Wei, M Sze, S.K Cheung, P.C.F Doerig, C Lescar, J DUKE-NUS MEDICAL SCHOOL casein kinase II protein kinase inhibitor protein tyrosine kinase amino acid sequence chemistry enzyme active site enzymology gene expression regulation genetics metabolism molecular model mutation phosphorylation Plasmodium falciparum X ray crystallography Amino Acid Sequence Casein Kinase II Catalytic Domain Crystallography, X-Ray Gene Expression Regulation, Enzymologic Models, Molecular Mutation Phosphorylation Plasmodium falciparum Protein Kinase Inhibitors Protein-Tyrosine Kinases 10.1038/s41598-018-25738-5 Scientific Reports 8 1 7365 2020-10-20T09:49:39Z 2020-10-20T09:49:39Z 2018 Article Ruiz-Carrillo, D, Lin, J, El Sahili, A, Wei, M, Sze, S.K, Cheung, P.C.F, Doerig, C, Lescar, J (2018). The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition. Scientific Reports 8 (1) : 7365. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-25738-5 2045-2322 https://scholarbank.nus.edu.sg/handle/10635/178413 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	casein kinase II protein kinase inhibitor protein tyrosine kinase amino acid sequence chemistry enzyme active site enzymology gene expression regulation genetics metabolism molecular model mutation phosphorylation Plasmodium falciparum X ray crystallography Amino Acid Sequence Casein Kinase II Catalytic Domain Crystallography, X-Ray Gene Expression Regulation, Enzymologic Models, Molecular Mutation Phosphorylation Plasmodium falciparum Protein Kinase Inhibitors Protein-Tyrosine Kinases
spellingShingle	casein kinase II protein kinase inhibitor protein tyrosine kinase amino acid sequence chemistry enzyme active site enzymology gene expression regulation genetics metabolism molecular model mutation phosphorylation Plasmodium falciparum X ray crystallography Amino Acid Sequence Casein Kinase II Catalytic Domain Crystallography, X-Ray Gene Expression Regulation, Enzymologic Models, Molecular Mutation Phosphorylation Plasmodium falciparum Protein Kinase Inhibitors Protein-Tyrosine Kinases Ruiz-Carrillo, D Lin, J El Sahili, A Wei, M Sze, S.K Cheung, P.C.F Doerig, C Lescar, J The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition
description	10.1038/s41598-018-25738-5
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Ruiz-Carrillo, D Lin, J El Sahili, A Wei, M Sze, S.K Cheung, P.C.F Doerig, C Lescar, J
format	Article
author	Ruiz-Carrillo, D Lin, J El Sahili, A Wei, M Sze, S.K Cheung, P.C.F Doerig, C Lescar, J
author_sort	Ruiz-Carrillo, D
title	The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition
title_short	The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition
title_full	The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition
title_fullStr	The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition
title_full_unstemmed	The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition
title_sort	protein kinase ck2 catalytic domain from plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178413
_version_	1779152282256932864

The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition

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