A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset

• Main Authors: Chin, W, Zhong, G, Pu, Q, Yang, C, Lou, W, De Sessions, P.F, Periaswamy, B, Lee, A, Liang, Z.C, Ding, X, Gao, S, Chu, C.W, Bianco, S, Bao, C, Tong, Y.W, Fan, W, Wu, M, Hedrick, J.L, Yang, Y.Y
• Other Authors: CHEMICAL & BIOMOLECULAR ENGINEERING
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: guanidine; imipenem; polycarbonate; vancomycin; antiinfective agent; polymer; antibiotics; antimicrobial activity; bacterial disease; biodegradation; drug resistance; infectious disease; microbial activity; Acinetobacter baumannii; Acinetobacter infection; animal cell; animal experiment; animal model; antibacterial activity; antibiotic resistance; Article; bacterial infection; bacterial peritonitis; controlled study; drug efficacy; drug therapeutic index; ED50; Escherichia coli; Escherichia coli infection; female; IC50; in vitro study; in vivo study; Klebsiella pneumoniae; Klebsiella pneumoniae infection; LD50; lung infection; macromolecule; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; minimum inhibitory concentration; mouse; nonhuman; Pseudomonas aeruginosa; Pseudomonas infection; rat; transcriptomics; animal; bacterium; C57BL mouse; cecum; chemistry; disease model; drug effects; hemolysis; Institute for Cancer Research mouse; isolation and purification; kinetics; ligation; microbial sensitivity test; microbiology; multidrug resistance; pharmacokinetics; puncture; sequence analysis; surgery; synthesis; therapeutic use; tissue distribution; Bacteria (microorganisms); Staphylococcus aureus; Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Cecum; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Female; Hemolysis; Kinetics; Ligation; Macromolecular Substances; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Microbial Sensitivity Tests; Polymers; Punctures; Sequence Analysis, RNA; Tissue Distribution
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178425
• Institution: National University of Singapore

10.1038/s41467-018-03325-6