A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset

10.1038/s41467-018-03325-6

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Main Authors:	Chin, W, Zhong, G, Pu, Q, Yang, C, Lou, W, De Sessions, P.F, Periaswamy, B, Lee, A, Liang, Z.C, Ding, X, Gao, S, Chu, C.W, Bianco, S, Bao, C, Tong, Y.W, Fan, W, Wu, M, Hedrick, J.L, Yang, Y.Y
Other Authors:	CHEMICAL & BIOMOLECULAR ENGINEERING
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	guanidine imipenem polycarbonate vancomycin antiinfective agent polymer antibiotics antimicrobial activity bacterial disease biodegradation drug resistance infectious disease microbial activity Acinetobacter baumannii Acinetobacter infection animal cell animal experiment animal model antibacterial activity antibiotic resistance Article bacterial infection bacterial peritonitis controlled study drug efficacy drug therapeutic index ED50 Escherichia coli Escherichia coli infection female IC50 in vitro study in vivo study Klebsiella pneumoniae Klebsiella pneumoniae infection LD50 lung infection macromolecule male methicillin resistant Staphylococcus aureus methicillin resistant Staphylococcus aureus infection minimum inhibitory concentration mouse nonhuman Pseudomonas aeruginosa Pseudomonas infection rat transcriptomics animal bacterium C57BL mouse cecum chemistry disease model drug effects hemolysis Institute for Cancer Research mouse isolation and purification kinetics ligation microbial sensitivity test microbiology multidrug resistance pharmacokinetics puncture sequence analysis surgery synthesis therapeutic use tissue distribution Bacteria (microorganisms) Staphylococcus aureus Animals Anti-Infective Agents Bacteria Bacterial Infections Cecum Disease Models, Animal Drug Resistance, Multiple, Bacterial Female Hemolysis Kinetics Ligation Macromolecular Substances Male Mice, Inbred C57BL Mice, Inbred ICR Microbial Sensitivity Tests Polymers Punctures Sequence Analysis, RNA Tissue Distribution
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178425
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1784252024-03-26T08:57:32Z A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset Chin, W Zhong, G Pu, Q Yang, C Lou, W De Sessions, P.F Periaswamy, B Lee, A Liang, Z.C Ding, X Gao, S Chu, C.W Bianco, S Bao, C Tong, Y.W Fan, W Wu, M Hedrick, J.L Yang, Y.Y CHEMICAL & BIOMOLECULAR ENGINEERING guanidine imipenem polycarbonate vancomycin antiinfective agent polymer antibiotics antimicrobial activity bacterial disease biodegradation drug resistance infectious disease microbial activity polymer Acinetobacter baumannii Acinetobacter infection animal cell animal experiment animal model antibacterial activity antibiotic resistance Article bacterial infection bacterial peritonitis controlled study drug efficacy drug therapeutic index ED50 Escherichia coli Escherichia coli infection female IC50 in vitro study in vivo study Klebsiella pneumoniae Klebsiella pneumoniae infection LD50 lung infection macromolecule male methicillin resistant Staphylococcus aureus methicillin resistant Staphylococcus aureus infection minimum inhibitory concentration mouse nonhuman Pseudomonas aeruginosa Pseudomonas infection rat transcriptomics animal bacterial infection bacterium C57BL mouse cecum chemistry disease model drug effects hemolysis Institute for Cancer Research mouse isolation and purification kinetics ligation macromolecule microbial sensitivity test microbiology multidrug resistance pharmacokinetics puncture sequence analysis surgery synthesis therapeutic use tissue distribution Bacteria (microorganisms) Staphylococcus aureus Animals Anti-Infective Agents Bacteria Bacterial Infections Cecum Disease Models, Animal Drug Resistance, Multiple, Bacterial Female Hemolysis Kinetics Ligation Macromolecular Substances Male Mice, Inbred C57BL Mice, Inbred ICR Microbial Sensitivity Tests Polymers Punctures Sequence Analysis, RNA Tissue Distribution 10.1038/s41467-018-03325-6 Nature Communications 9 1 917 2020-10-20T09:54:28Z 2020-10-20T09:54:28Z 2018 Article Chin, W, Zhong, G, Pu, Q, Yang, C, Lou, W, De Sessions, P.F, Periaswamy, B, Lee, A, Liang, Z.C, Ding, X, Gao, S, Chu, C.W, Bianco, S, Bao, C, Tong, Y.W, Fan, W, Wu, M, Hedrick, J.L, Yang, Y.Y (2018). A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset. Nature Communications 9 (1) : 917. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-03325-6 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178425 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	guanidine imipenem polycarbonate vancomycin antiinfective agent polymer antibiotics antimicrobial activity bacterial disease biodegradation drug resistance infectious disease microbial activity polymer Acinetobacter baumannii Acinetobacter infection animal cell animal experiment animal model antibacterial activity antibiotic resistance Article bacterial infection bacterial peritonitis controlled study drug efficacy drug therapeutic index ED50 Escherichia coli Escherichia coli infection female IC50 in vitro study in vivo study Klebsiella pneumoniae Klebsiella pneumoniae infection LD50 lung infection macromolecule male methicillin resistant Staphylococcus aureus methicillin resistant Staphylococcus aureus infection minimum inhibitory concentration mouse nonhuman Pseudomonas aeruginosa Pseudomonas infection rat transcriptomics animal bacterial infection bacterium C57BL mouse cecum chemistry disease model drug effects hemolysis Institute for Cancer Research mouse isolation and purification kinetics ligation macromolecule microbial sensitivity test microbiology multidrug resistance pharmacokinetics puncture sequence analysis surgery synthesis therapeutic use tissue distribution Bacteria (microorganisms) Staphylococcus aureus Animals Anti-Infective Agents Bacteria Bacterial Infections Cecum Disease Models, Animal Drug Resistance, Multiple, Bacterial Female Hemolysis Kinetics Ligation Macromolecular Substances Male Mice, Inbred C57BL Mice, Inbred ICR Microbial Sensitivity Tests Polymers Punctures Sequence Analysis, RNA Tissue Distribution
spellingShingle	guanidine imipenem polycarbonate vancomycin antiinfective agent polymer antibiotics antimicrobial activity bacterial disease biodegradation drug resistance infectious disease microbial activity polymer Acinetobacter baumannii Acinetobacter infection animal cell animal experiment animal model antibacterial activity antibiotic resistance Article bacterial infection bacterial peritonitis controlled study drug efficacy drug therapeutic index ED50 Escherichia coli Escherichia coli infection female IC50 in vitro study in vivo study Klebsiella pneumoniae Klebsiella pneumoniae infection LD50 lung infection macromolecule male methicillin resistant Staphylococcus aureus methicillin resistant Staphylococcus aureus infection minimum inhibitory concentration mouse nonhuman Pseudomonas aeruginosa Pseudomonas infection rat transcriptomics animal bacterial infection bacterium C57BL mouse cecum chemistry disease model drug effects hemolysis Institute for Cancer Research mouse isolation and purification kinetics ligation macromolecule microbial sensitivity test microbiology multidrug resistance pharmacokinetics puncture sequence analysis surgery synthesis therapeutic use tissue distribution Bacteria (microorganisms) Staphylococcus aureus Animals Anti-Infective Agents Bacteria Bacterial Infections Cecum Disease Models, Animal Drug Resistance, Multiple, Bacterial Female Hemolysis Kinetics Ligation Macromolecular Substances Male Mice, Inbred C57BL Mice, Inbred ICR Microbial Sensitivity Tests Polymers Punctures Sequence Analysis, RNA Tissue Distribution Chin, W Zhong, G Pu, Q Yang, C Lou, W De Sessions, P.F Periaswamy, B Lee, A Liang, Z.C Ding, X Gao, S Chu, C.W Bianco, S Bao, C Tong, Y.W Fan, W Wu, M Hedrick, J.L Yang, Y.Y A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
description	10.1038/s41467-018-03325-6
author2	CHEMICAL & BIOMOLECULAR ENGINEERING
author_facet	CHEMICAL & BIOMOLECULAR ENGINEERING Chin, W Zhong, G Pu, Q Yang, C Lou, W De Sessions, P.F Periaswamy, B Lee, A Liang, Z.C Ding, X Gao, S Chu, C.W Bianco, S Bao, C Tong, Y.W Fan, W Wu, M Hedrick, J.L Yang, Y.Y
format	Article
author	Chin, W Zhong, G Pu, Q Yang, C Lou, W De Sessions, P.F Periaswamy, B Lee, A Liang, Z.C Ding, X Gao, S Chu, C.W Bianco, S Bao, C Tong, Y.W Fan, W Wu, M Hedrick, J.L Yang, Y.Y
author_sort	Chin, W
title	A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
title_short	A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
title_full	A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
title_fullStr	A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
title_full_unstemmed	A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
title_sort	macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178425
_version_	1795301222121472000

A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset

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