A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection

• Main Authors: Malavige, G.N, Wijewickrama, A, Fernando, S, Jeewandara, C, Ginneliya, A, Samarasekara, S, Madushanka, P, Punchihewa, C, Paranavitane, S, Idampitiya, D, Wanigatunga, C, Dissanayake, H, Prathapan, S, Gomes, L, Aman, S.A.B, John, A.S, Ogg, G.S
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: antiallergic agent; antihistaminic agent; cyproheptadine; histamine H1 receptor antagonist; rupatadine; acute disease; adult; animal; C57BL mouse; dengue; Dengue virus; disease model; double blind procedure; drug effect; endothelium; female; human; male; metabolism; mouse; pathogenicity; preliminary data; Sri Lanka; thrombocyte; treatment outcome; umbilical vein endothelial cell; Acute Disease; Adult; Animals; Anti-Allergic Agents; Blood Platelets; Cyproheptadine; Dengue; Dengue Virus; Disease Models, Animal; Double-Blind Method; Endothelium; Female; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Preliminary Data; Treatment Outcome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178426
• Institution: National University of Singapore

10.1038/s41598-018-22285-x