Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis

• Main Authors: Brilha, S, Ong, C.W.M, Weksler, B, Romero, N, Couraud, P.-O, Friedland, J.S
• Other Authors: MEDICINE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: gelatinase B; sonic hedgehog protein; blood brain barrier; cell culture; cell line; central nervous system tuberculosis; conditioned medium; enzyme linked immunosorbent assay; genetics; human; metabolism; Mycobacterium tuberculosis; pathogenicity; physiology; signal transduction; tight junction; Blood-Brain Barrier; Cell Line; Cells, Cultured; Culture Media, Conditioned; Enzyme-Linked Immunosorbent Assay; Hedgehog Proteins; Humans; Matrix Metalloproteinase 9; Signal Transduction; Tight Junctions; Tuberculosis, Central Nervous System
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178557
• Institution: National University of Singapore

10.1038/s41598-017-16250-3