The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

• Main Authors: Hosokawa, K, MacArthur, B.D, Ikushima, Y.M, Toyama, H, Masuhiro, Y, Hanazawa, S, Suda, T, Arai, F
• Other Authors: MEDICINE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: Pot1 protein; reactive oxygen metabolite; telomere binding protein; unclassified drug; DNA binding protein; POT1 protein, mouse; age; cells and cell components; chromosome; DNA; gene expression; protein; reactive oxygen species; animal cell; apoptosis; Article; cell activity; cell aging; cell differentiation; cell function; cell protection; cell survival; controlled study; DNA damage response; down regulation; ex vivo study; hematopoietic stem cell; human; human cell; microarray analysis; mouse; nonhuman; oxidative phosphorylation; protein expression; protein function; rejuvenation; senescence; stem cell culture; stem cell expansion; stem cell self-renewal; animal; cell culture; DNA damage; genetics; metabolism; physiology; telomere; Animals; Cells, Cultured; Cellular Senescence; DNA Damage; DNA-Binding Proteins; Hematopoietic Stem Cells; Humans; Mice; Reactive Oxygen Species; Telomere
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178570
• Institution: National University of Singapore

10.1038/s41467-017-00935-4