Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells

10.1038/s41467-017-00627-z

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Main Authors:	Fehlings, M, Simoni, Y, Penny, H.L, Becht, E, Loh, C.Y, Gubin, M.M, Ward, J.P, Wong, S.C, Schreiber, R.D, Newell, E.W
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	3 methylcholanthrene CD27 antigen CD38 antigen chemokine receptor CXCR3 cytotoxic T lymphocyte antigen 4 antibody granzyme B hepatitis A virus cellular receptor 2 Hermes antigen interleukin 2 receptor alpha interleukin 7 receptor L selectin monoclonal antibody programmed death 1 antibody programmed death 1 ligand 1 tetramer unclassified drug cytotoxic T lymphocyte antigen 4 immunological antineoplastic agent programmed death 1 receptor tumor antigen antigen cancer cells and cell components disease treatment heterogeneity immune system phenotype rodent tumor algorithm animal cell animal experiment animal model animal tissue Article CD8+ T lymphocyte cell differentiation cell infiltration cell migration comparative study controlled study flow cytometry gene expression immunocompetent cell immunotherapy lymph node male mass cytometry melanoma mouse neoplasm nonhuman protein expression sarcoma tumor immunity upregulation wild type animal antagonists and inhibitors chemically induced drug effects experimental sarcoma immunology immunophenotyping tumor associated leukocyte Murinae Mus Animals Antigens, Neoplasm Antineoplastic Agents, Immunological CD8-Positive T-Lymphocytes CTLA-4 Antigen Immunophenotyping Immunotherapy Lymphocytes, Tumor-Infiltrating Methylcholanthrene Mice Programmed Cell Death 1 Receptor Sarcoma, Experimental
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178577
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1785772024-11-12T14:02:16Z Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells Fehlings, M Simoni, Y Penny, H.L Becht, E Loh, C.Y Gubin, M.M Ward, J.P Wong, S.C Schreiber, R.D Newell, E.W MICROBIOLOGY AND IMMUNOLOGY 3 methylcholanthrene CD27 antigen CD38 antigen chemokine receptor CXCR3 cytotoxic T lymphocyte antigen 4 antibody granzyme B hepatitis A virus cellular receptor 2 Hermes antigen interleukin 2 receptor alpha interleukin 7 receptor L selectin monoclonal antibody programmed death 1 antibody programmed death 1 ligand 1 tetramer unclassified drug 3 methylcholanthrene cytotoxic T lymphocyte antigen 4 immunological antineoplastic agent programmed death 1 receptor tumor antigen antigen cancer cells and cell components disease treatment heterogeneity immune system phenotype rodent tumor algorithm animal cell animal experiment animal model animal tissue Article CD8+ T lymphocyte cell differentiation cell infiltration cell migration comparative study controlled study flow cytometry gene expression immunocompetent cell immunotherapy lymph node male mass cytometry melanoma mouse neoplasm nonhuman phenotype protein expression sarcoma tumor immunity upregulation wild type animal antagonists and inhibitors CD8+ T lymphocyte chemically induced drug effects experimental sarcoma immunology immunophenotyping immunotherapy tumor associated leukocyte Murinae Mus Animals Antigens, Neoplasm Antineoplastic Agents, Immunological CD8-Positive T-Lymphocytes CTLA-4 Antigen Immunophenotyping Immunotherapy Lymphocytes, Tumor-Infiltrating Methylcholanthrene Mice Programmed Cell Death 1 Receptor Sarcoma, Experimental 10.1038/s41467-017-00627-z Nature Communications 8 1 562 2020-10-20T10:23:47Z 2020-10-20T10:23:47Z 2017 Article Fehlings, M, Simoni, Y, Penny, H.L, Becht, E, Loh, C.Y, Gubin, M.M, Ward, J.P, Wong, S.C, Schreiber, R.D, Newell, E.W (2017). Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells. Nature Communications 8 (1) : 562. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-00627-z 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178577 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	3 methylcholanthrene CD27 antigen CD38 antigen chemokine receptor CXCR3 cytotoxic T lymphocyte antigen 4 antibody granzyme B hepatitis A virus cellular receptor 2 Hermes antigen interleukin 2 receptor alpha interleukin 7 receptor L selectin monoclonal antibody programmed death 1 antibody programmed death 1 ligand 1 tetramer unclassified drug 3 methylcholanthrene cytotoxic T lymphocyte antigen 4 immunological antineoplastic agent programmed death 1 receptor tumor antigen antigen cancer cells and cell components disease treatment heterogeneity immune system phenotype rodent tumor algorithm animal cell animal experiment animal model animal tissue Article CD8+ T lymphocyte cell differentiation cell infiltration cell migration comparative study controlled study flow cytometry gene expression immunocompetent cell immunotherapy lymph node male mass cytometry melanoma mouse neoplasm nonhuman phenotype protein expression sarcoma tumor immunity upregulation wild type animal antagonists and inhibitors CD8+ T lymphocyte chemically induced drug effects experimental sarcoma immunology immunophenotyping immunotherapy tumor associated leukocyte Murinae Mus Animals Antigens, Neoplasm Antineoplastic Agents, Immunological CD8-Positive T-Lymphocytes CTLA-4 Antigen Immunophenotyping Immunotherapy Lymphocytes, Tumor-Infiltrating Methylcholanthrene Mice Programmed Cell Death 1 Receptor Sarcoma, Experimental
spellingShingle	3 methylcholanthrene CD27 antigen CD38 antigen chemokine receptor CXCR3 cytotoxic T lymphocyte antigen 4 antibody granzyme B hepatitis A virus cellular receptor 2 Hermes antigen interleukin 2 receptor alpha interleukin 7 receptor L selectin monoclonal antibody programmed death 1 antibody programmed death 1 ligand 1 tetramer unclassified drug 3 methylcholanthrene cytotoxic T lymphocyte antigen 4 immunological antineoplastic agent programmed death 1 receptor tumor antigen antigen cancer cells and cell components disease treatment heterogeneity immune system phenotype rodent tumor algorithm animal cell animal experiment animal model animal tissue Article CD8+ T lymphocyte cell differentiation cell infiltration cell migration comparative study controlled study flow cytometry gene expression immunocompetent cell immunotherapy lymph node male mass cytometry melanoma mouse neoplasm nonhuman phenotype protein expression sarcoma tumor immunity upregulation wild type animal antagonists and inhibitors CD8+ T lymphocyte chemically induced drug effects experimental sarcoma immunology immunophenotyping immunotherapy tumor associated leukocyte Murinae Mus Animals Antigens, Neoplasm Antineoplastic Agents, Immunological CD8-Positive T-Lymphocytes CTLA-4 Antigen Immunophenotyping Immunotherapy Lymphocytes, Tumor-Infiltrating Methylcholanthrene Mice Programmed Cell Death 1 Receptor Sarcoma, Experimental Fehlings, M Simoni, Y Penny, H.L Becht, E Loh, C.Y Gubin, M.M Ward, J.P Wong, S.C Schreiber, R.D Newell, E.W Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
description	10.1038/s41467-017-00627-z
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Fehlings, M Simoni, Y Penny, H.L Becht, E Loh, C.Y Gubin, M.M Ward, J.P Wong, S.C Schreiber, R.D Newell, E.W
format	Article
author	Fehlings, M Simoni, Y Penny, H.L Becht, E Loh, C.Y Gubin, M.M Ward, J.P Wong, S.C Schreiber, R.D Newell, E.W
author_sort	Fehlings, M
title	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_short	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_full	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_fullStr	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_full_unstemmed	Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
title_sort	checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific cd8+ t cells
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178577
_version_	1821226868303462400

Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells

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