Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells

• Main Authors: Fehlings, M, Simoni, Y, Penny, H.L, Becht, E, Loh, C.Y, Gubin, M.M, Ward, J.P, Wong, S.C, Schreiber, R.D, Newell, E.W
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: 3 methylcholanthrene; CD27 antigen; CD38 antigen; chemokine receptor CXCR3; cytotoxic T lymphocyte antigen 4 antibody; granzyme B; hepatitis A virus cellular receptor 2; Hermes antigen; interleukin 2 receptor alpha; interleukin 7 receptor; L selectin; monoclonal antibody; programmed death 1 antibody; programmed death 1 ligand 1; tetramer; unclassified drug; cytotoxic T lymphocyte antigen 4; immunological antineoplastic agent; programmed death 1 receptor; tumor antigen; antigen; cancer; cells and cell components; disease treatment; heterogeneity; immune system; phenotype; rodent; tumor; algorithm; animal cell; animal experiment; animal model; animal tissue; Article; CD8+ T lymphocyte; cell differentiation; cell infiltration; cell migration; comparative study; controlled study; flow cytometry; gene expression; immunocompetent cell; immunotherapy; lymph node; male; mass cytometry; melanoma; mouse; neoplasm; nonhuman; protein expression; sarcoma; tumor immunity; upregulation; wild type; animal; antagonists and inhibitors; chemically induced; drug effects; experimental sarcoma; immunology; immunophenotyping; tumor associated leukocyte; Murinae; Mus; Animals; Antigens, Neoplasm; Antineoplastic Agents, Immunological; CD8-Positive T-Lymphocytes; CTLA-4 Antigen; Immunophenotyping; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Methylcholanthrene; Mice; Programmed Cell Death 1 Receptor; Sarcoma, Experimental
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178577
• Institution: National University of Singapore

10.1038/s41467-017-00627-z