A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing

• Main Authors: Prapa, M, Caldrer, S, Spano, C, Bestagno, M, Golinelli, G, Grisendi, G, Petrachi, T, Conte, P, Horwitz, E.M, Campana, D, Paolucci, P, Dominici, M
• Other Authors: PAEDIATRICS
• Format: Article
• Published: 2020
• Subjects: aldesleukin; CD137 antigen; CD3 zeta antigen; gamma interferon; ganglioside GD2; ganglioside GD2 4 1BB chimeric antigen receptor monoclonal antibody; lymphocyte antigen; monoclonal antibody; retrovirus vector; single chain fragment variable antibody; tumor necrosis factor related apoptosis inducing ligand; unclassified drug; ganglioside; ganglioside, GD2; green fluorescent protein; lymphocyte antigen receptor; TNFSF10 protein, human; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; cancer inhibition; cell based gene therapy; controlled study; drug cytotoxicity; drug targeting; genetic transduction; human; human cell; in vitro study; in vivo study; lymphocytic infiltration; lymphocytotoxicity; mouse; neuroblastoma; neuroectoderm tumor; nonhuman; protein analysis; protein expression; protein secretion; reverse transcription polymerase chain reaction; SH SY5Y cell line; SKnBE cell line; T lymphocyte; tumor xenograft; adoptive immunotherapy; animal; cytotoxicity; drug screening; flow cytometry; fluorescence microscopy; genetics; HEK293 cell line; immunology; metabolism; nonobese diabetic mouse; pathology; procedures; SCID mouse; transplantation; tumor cell line; Animals; Antigens, CD137; Apoptosis; Cell Line, Tumor; Cytotoxicity, Immunologic; Flow Cytometry; Gangliosides; Green Fluorescent Proteins; HEK293 Cells; Humans; Immunotherapy, Adoptive; Interferon-gamma; Mice, Inbred NOD; Mice, SCID; Microscopy, Fluorescence; Neuroblastoma; Receptors, Antigen, T-Cell; Single-Chain Antibodies; T-Lymphocytes; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180938
• Institution: National University of Singapore

10.18632/oncotarget.4670