A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing

10.18632/oncotarget.4670

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Main Authors:	Prapa, M, Caldrer, S, Spano, C, Bestagno, M, Golinelli, G, Grisendi, G, Petrachi, T, Conte, P, Horwitz, E.M, Campana, D, Paolucci, P, Dominici, M
Other Authors:	PAEDIATRICS
Format:	Article
Published:	2020
Subjects:	aldesleukin CD137 antigen CD3 zeta antigen gamma interferon ganglioside GD2 ganglioside GD2 4 1BB chimeric antigen receptor monoclonal antibody lymphocyte antigen monoclonal antibody retrovirus vector single chain fragment variable antibody tumor necrosis factor related apoptosis inducing ligand unclassified drug ganglioside ganglioside, GD2 green fluorescent protein lymphocyte antigen receptor TNFSF10 protein, human animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell based gene therapy controlled study drug cytotoxicity drug targeting genetic transduction human human cell in vitro study in vivo study lymphocytic infiltration lymphocytotoxicity mouse neuroblastoma neuroectoderm tumor nonhuman protein analysis protein expression protein secretion reverse transcription polymerase chain reaction SH SY5Y cell line SKnBE cell line T lymphocyte tumor xenograft adoptive immunotherapy animal cytotoxicity drug screening flow cytometry fluorescence microscopy genetics HEK293 cell line immunology metabolism nonobese diabetic mouse pathology procedures SCID mouse transplantation tumor cell line Animals Antigens, CD137 Apoptosis Cell Line, Tumor Cytotoxicity, Immunologic Flow Cytometry Gangliosides Green Fluorescent Proteins HEK293 Cells Humans Immunotherapy, Adoptive Interferon-gamma Mice, Inbred NOD Mice, SCID Microscopy, Fluorescence Neuroblastoma Receptors, Antigen, T-Cell Single-Chain Antibodies T-Lymphocytes TNF-Related Apoptosis-Inducing Ligand Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180938
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1809382024-04-24T06:51:59Z A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing Prapa, M Caldrer, S Spano, C Bestagno, M Golinelli, G Grisendi, G Petrachi, T Conte, P Horwitz, E.M Campana, D Paolucci, P Dominici, M PAEDIATRICS aldesleukin CD137 antigen CD3 zeta antigen gamma interferon ganglioside GD2 ganglioside GD2 4 1BB chimeric antigen receptor monoclonal antibody lymphocyte antigen monoclonal antibody retrovirus vector single chain fragment variable antibody tumor necrosis factor related apoptosis inducing ligand unclassified drug CD137 antigen gamma interferon ganglioside ganglioside, GD2 green fluorescent protein lymphocyte antigen receptor single chain fragment variable antibody TNFSF10 protein, human tumor necrosis factor related apoptosis inducing ligand animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell based gene therapy controlled study drug cytotoxicity drug targeting genetic transduction human human cell in vitro study in vivo study lymphocytic infiltration lymphocytotoxicity mouse neuroblastoma neuroectoderm tumor nonhuman protein analysis protein expression protein secretion reverse transcription polymerase chain reaction SH SY5Y cell line SKnBE cell line T lymphocyte tumor xenograft adoptive immunotherapy animal cytotoxicity drug screening flow cytometry fluorescence microscopy genetics HEK293 cell line immunology metabolism neuroblastoma nonobese diabetic mouse pathology procedures SCID mouse transplantation tumor cell line Animals Antigens, CD137 Apoptosis Cell Line, Tumor Cytotoxicity, Immunologic Flow Cytometry Gangliosides Green Fluorescent Proteins HEK293 Cells Humans Immunotherapy, Adoptive Interferon-gamma Mice, Inbred NOD Mice, SCID Microscopy, Fluorescence Neuroblastoma Receptors, Antigen, T-Cell Single-Chain Antibodies T-Lymphocytes TNF-Related Apoptosis-Inducing Ligand Xenograft Model Antitumor Assays 10.18632/oncotarget.4670 Oncotarget 6 28 24884-24894 2020-10-27T05:47:21Z 2020-10-27T05:47:21Z 2015 Article Prapa, M, Caldrer, S, Spano, C, Bestagno, M, Golinelli, G, Grisendi, G, Petrachi, T, Conte, P, Horwitz, E.M, Campana, D, Paolucci, P, Dominici, M (2015). A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing. Oncotarget 6 (28) : 24884-24894. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4670 19492553 https://scholarbank.nus.edu.sg/handle/10635/180938 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	aldesleukin CD137 antigen CD3 zeta antigen gamma interferon ganglioside GD2 ganglioside GD2 4 1BB chimeric antigen receptor monoclonal antibody lymphocyte antigen monoclonal antibody retrovirus vector single chain fragment variable antibody tumor necrosis factor related apoptosis inducing ligand unclassified drug CD137 antigen gamma interferon ganglioside ganglioside, GD2 green fluorescent protein lymphocyte antigen receptor single chain fragment variable antibody TNFSF10 protein, human tumor necrosis factor related apoptosis inducing ligand animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell based gene therapy controlled study drug cytotoxicity drug targeting genetic transduction human human cell in vitro study in vivo study lymphocytic infiltration lymphocytotoxicity mouse neuroblastoma neuroectoderm tumor nonhuman protein analysis protein expression protein secretion reverse transcription polymerase chain reaction SH SY5Y cell line SKnBE cell line T lymphocyte tumor xenograft adoptive immunotherapy animal cytotoxicity drug screening flow cytometry fluorescence microscopy genetics HEK293 cell line immunology metabolism neuroblastoma nonobese diabetic mouse pathology procedures SCID mouse transplantation tumor cell line Animals Antigens, CD137 Apoptosis Cell Line, Tumor Cytotoxicity, Immunologic Flow Cytometry Gangliosides Green Fluorescent Proteins HEK293 Cells Humans Immunotherapy, Adoptive Interferon-gamma Mice, Inbred NOD Mice, SCID Microscopy, Fluorescence Neuroblastoma Receptors, Antigen, T-Cell Single-Chain Antibodies T-Lymphocytes TNF-Related Apoptosis-Inducing Ligand Xenograft Model Antitumor Assays
spellingShingle	aldesleukin CD137 antigen CD3 zeta antigen gamma interferon ganglioside GD2 ganglioside GD2 4 1BB chimeric antigen receptor monoclonal antibody lymphocyte antigen monoclonal antibody retrovirus vector single chain fragment variable antibody tumor necrosis factor related apoptosis inducing ligand unclassified drug CD137 antigen gamma interferon ganglioside ganglioside, GD2 green fluorescent protein lymphocyte antigen receptor single chain fragment variable antibody TNFSF10 protein, human tumor necrosis factor related apoptosis inducing ligand animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell based gene therapy controlled study drug cytotoxicity drug targeting genetic transduction human human cell in vitro study in vivo study lymphocytic infiltration lymphocytotoxicity mouse neuroblastoma neuroectoderm tumor nonhuman protein analysis protein expression protein secretion reverse transcription polymerase chain reaction SH SY5Y cell line SKnBE cell line T lymphocyte tumor xenograft adoptive immunotherapy animal cytotoxicity drug screening flow cytometry fluorescence microscopy genetics HEK293 cell line immunology metabolism neuroblastoma nonobese diabetic mouse pathology procedures SCID mouse transplantation tumor cell line Animals Antigens, CD137 Apoptosis Cell Line, Tumor Cytotoxicity, Immunologic Flow Cytometry Gangliosides Green Fluorescent Proteins HEK293 Cells Humans Immunotherapy, Adoptive Interferon-gamma Mice, Inbred NOD Mice, SCID Microscopy, Fluorescence Neuroblastoma Receptors, Antigen, T-Cell Single-Chain Antibodies T-Lymphocytes TNF-Related Apoptosis-Inducing Ligand Xenograft Model Antitumor Assays Prapa, M Caldrer, S Spano, C Bestagno, M Golinelli, G Grisendi, G Petrachi, T Conte, P Horwitz, E.M Campana, D Paolucci, P Dominici, M A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
description	10.18632/oncotarget.4670
author2	PAEDIATRICS
author_facet	PAEDIATRICS Prapa, M Caldrer, S Spano, C Bestagno, M Golinelli, G Grisendi, G Petrachi, T Conte, P Horwitz, E.M Campana, D Paolucci, P Dominici, M
format	Article
author	Prapa, M Caldrer, S Spano, C Bestagno, M Golinelli, G Grisendi, G Petrachi, T Conte, P Horwitz, E.M Campana, D Paolucci, P Dominici, M
author_sort	Prapa, M
title	A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
title_short	A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
title_full	A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
title_fullStr	A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
title_full_unstemmed	A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
title_sort	novel anti-gd2/4-1bb chimeric antigen receptor triggers neuroblastoma cell killing
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180938
_version_	1800914615930978304

A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing

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