A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing

A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing

10.18632/oncotarget.4670

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Bibliographic Details
Main Authors:	Prapa, M, Caldrer, S, Spano, C, Bestagno, M, Golinelli, G, Grisendi, G, Petrachi, T, Conte, P, Horwitz, E.M, Campana, D, Paolucci, P, Dominici, M
Other Authors:	PAEDIATRICS
Format:	Article
Published:	2020
Subjects:	aldesleukin CD137 antigen CD3 zeta antigen gamma interferon ganglioside GD2 ganglioside GD2 4 1BB chimeric antigen receptor monoclonal antibody lymphocyte antigen monoclonal antibody retrovirus vector single chain fragment variable antibody tumor necrosis factor related apoptosis inducing ligand unclassified drug ganglioside ganglioside, GD2 green fluorescent protein lymphocyte antigen receptor TNFSF10 protein, human animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell based gene therapy controlled study drug cytotoxicity drug targeting genetic transduction human human cell in vitro study in vivo study lymphocytic infiltration lymphocytotoxicity mouse neuroblastoma neuroectoderm tumor nonhuman protein analysis protein expression protein secretion reverse transcription polymerase chain reaction SH SY5Y cell line SKnBE cell line T lymphocyte tumor xenograft adoptive immunotherapy animal cytotoxicity drug screening flow cytometry fluorescence microscopy genetics HEK293 cell line immunology metabolism nonobese diabetic mouse pathology procedures SCID mouse transplantation tumor cell line Animals Antigens, CD137 Apoptosis Cell Line, Tumor Cytotoxicity, Immunologic Flow Cytometry Gangliosides Green Fluorescent Proteins HEK293 Cells Humans Immunotherapy, Adoptive Interferon-gamma Mice, Inbred NOD Mice, SCID Microscopy, Fluorescence Neuroblastoma Receptors, Antigen, T-Cell Single-Chain Antibodies T-Lymphocytes TNF-Related Apoptosis-Inducing Ligand Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180938
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Institution:	National University of Singapore

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