APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

• Main Authors: Li, Z, Abraham, B.J, Berezovskaya, A, Farah, N, Liu, Y, Leon, T, Fielding, A, Tan, S.H, Sanda, T, Weintraub, A.S, Li, B, Shen, S, Zhang, J, Mansour, M.R, Young, R.A, Look, A.T
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: apolipoprotein B mRNA editing enzyme catalytic polypeptide like; cytidine deaminase; 5' untranslated region; DNA; DNA binding protein; LIM protein; LMO1 protein, human; protein c Myb; small interfering RNA; transcription factor; transcriptome; tumor protein; acute lymphoblastic leukemia; Article; binding site; chromatin immunoprecipitation; controlled study; gene frequency; gene mutation; gene translocation; human; human cell; human tissue; LMO1 gene; luciferase assay; lymphoid cell; oncogene; priority journal; protein binding; protein motif; quantitative analysis; reverse transcription polymerase chain reaction; single nucleotide polymorphism; somatic mutation; transcription initiation site; antagonists and inhibitors; biosynthesis; child; enhancer region; gene expression regulation; genetics; Jurkat cell line; metabolism; nucleotide sequence; oncogene myb; point mutation; RNA interference; tumor cell line; 5' Untranslated Regions; APOBEC Deaminases; Base Sequence; Binding Sites; Cell Line, Tumor; Child; Chromatin Immunoprecipitation; DNA, Neoplasm; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation, Leukemic; Genes, myb; Humans; Jurkat Cells; LIM Domain Proteins; Neoplasm Proteins; Point Mutation; Polymorphism, Single Nucleotide; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-myb; RNA Interference; RNA, Small Interfering; Transcription Factors; Transcriptome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179091
• Institution: National University of Singapore

10.1038/leu.2017.75