APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

10.1038/leu.2017.75

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Main Authors:	Li, Z, Abraham, B.J, Berezovskaya, A, Farah, N, Liu, Y, Leon, T, Fielding, A, Tan, S.H, Sanda, T, Weintraub, A.S, Li, B, Shen, S, Zhang, J, Mansour, M.R, Young, R.A, Look, A.T
Other Authors:	MEDICINE
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	apolipoprotein B mRNA editing enzyme catalytic polypeptide like cytidine deaminase 5' untranslated region DNA DNA binding protein LIM protein LMO1 protein, human protein c Myb small interfering RNA transcription factor transcriptome tumor protein acute lymphoblastic leukemia Article binding site chromatin immunoprecipitation controlled study gene frequency gene mutation gene translocation human human cell human tissue LMO1 gene luciferase assay lymphoid cell oncogene priority journal protein binding protein motif quantitative analysis reverse transcription polymerase chain reaction single nucleotide polymorphism somatic mutation transcription initiation site antagonists and inhibitors biosynthesis child enhancer region gene expression regulation genetics Jurkat cell line metabolism nucleotide sequence oncogene myb point mutation RNA interference tumor cell line 5' Untranslated Regions APOBEC Deaminases Base Sequence Binding Sites Cell Line, Tumor Child Chromatin Immunoprecipitation DNA, Neoplasm DNA-Binding Proteins Enhancer Elements, Genetic Gene Expression Regulation, Leukemic Genes, myb Humans Jurkat Cells LIM Domain Proteins Neoplasm Proteins Point Mutation Polymorphism, Single Nucleotide Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Proto-Oncogene Proteins c-myb RNA Interference RNA, Small Interfering Transcription Factors Transcriptome
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179091
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1790912024-11-12T01:45:51Z APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL Li, Z Abraham, B.J Berezovskaya, A Farah, N Liu, Y Leon, T Fielding, A Tan, S.H Sanda, T Weintraub, A.S Li, B Shen, S Zhang, J Mansour, M.R Young, R.A Look, A.T MEDICINE CANCER SCIENCE INSTITUTE OF SINGAPORE apolipoprotein B mRNA editing enzyme catalytic polypeptide like cytidine deaminase 5' untranslated region apolipoprotein B mRNA editing enzyme catalytic polypeptide like DNA DNA binding protein LIM protein LMO1 protein, human protein c Myb small interfering RNA transcription factor transcriptome tumor protein acute lymphoblastic leukemia Article binding site chromatin immunoprecipitation controlled study gene frequency gene mutation gene translocation human human cell human tissue LMO1 gene luciferase assay lymphoid cell oncogene priority journal protein binding protein motif quantitative analysis reverse transcription polymerase chain reaction single nucleotide polymorphism somatic mutation transcription initiation site 5' untranslated region acute lymphoblastic leukemia antagonists and inhibitors biosynthesis child enhancer region gene expression regulation genetics Jurkat cell line metabolism nucleotide sequence oncogene myb point mutation RNA interference tumor cell line 5' Untranslated Regions APOBEC Deaminases Base Sequence Binding Sites Cell Line, Tumor Child Chromatin Immunoprecipitation DNA, Neoplasm DNA-Binding Proteins Enhancer Elements, Genetic Gene Expression Regulation, Leukemic Genes, myb Humans Jurkat Cells LIM Domain Proteins Neoplasm Proteins Point Mutation Polymorphism, Single Nucleotide Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Proto-Oncogene Proteins c-myb RNA Interference RNA, Small Interfering Transcription Factors Transcriptome 10.1038/leu.2017.75 Leukemia 31 10 2057-2064 2020-10-22T07:37:04Z 2020-10-22T07:37:04Z 2017 Article Li, Z, Abraham, B.J, Berezovskaya, A, Farah, N, Liu, Y, Leon, T, Fielding, A, Tan, S.H, Sanda, T, Weintraub, A.S, Li, B, Shen, S, Zhang, J, Mansour, M.R, Young, R.A, Look, A.T (2017). APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. Leukemia 31 (10) : 2057-2064. ScholarBank@NUS Repository. https://doi.org/10.1038/leu.2017.75 08876924 https://scholarbank.nus.edu.sg/handle/10635/179091 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	apolipoprotein B mRNA editing enzyme catalytic polypeptide like cytidine deaminase 5' untranslated region apolipoprotein B mRNA editing enzyme catalytic polypeptide like DNA DNA binding protein LIM protein LMO1 protein, human protein c Myb small interfering RNA transcription factor transcriptome tumor protein acute lymphoblastic leukemia Article binding site chromatin immunoprecipitation controlled study gene frequency gene mutation gene translocation human human cell human tissue LMO1 gene luciferase assay lymphoid cell oncogene priority journal protein binding protein motif quantitative analysis reverse transcription polymerase chain reaction single nucleotide polymorphism somatic mutation transcription initiation site 5' untranslated region acute lymphoblastic leukemia antagonists and inhibitors biosynthesis child enhancer region gene expression regulation genetics Jurkat cell line metabolism nucleotide sequence oncogene myb point mutation RNA interference tumor cell line 5' Untranslated Regions APOBEC Deaminases Base Sequence Binding Sites Cell Line, Tumor Child Chromatin Immunoprecipitation DNA, Neoplasm DNA-Binding Proteins Enhancer Elements, Genetic Gene Expression Regulation, Leukemic Genes, myb Humans Jurkat Cells LIM Domain Proteins Neoplasm Proteins Point Mutation Polymorphism, Single Nucleotide Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Proto-Oncogene Proteins c-myb RNA Interference RNA, Small Interfering Transcription Factors Transcriptome
spellingShingle	apolipoprotein B mRNA editing enzyme catalytic polypeptide like cytidine deaminase 5' untranslated region apolipoprotein B mRNA editing enzyme catalytic polypeptide like DNA DNA binding protein LIM protein LMO1 protein, human protein c Myb small interfering RNA transcription factor transcriptome tumor protein acute lymphoblastic leukemia Article binding site chromatin immunoprecipitation controlled study gene frequency gene mutation gene translocation human human cell human tissue LMO1 gene luciferase assay lymphoid cell oncogene priority journal protein binding protein motif quantitative analysis reverse transcription polymerase chain reaction single nucleotide polymorphism somatic mutation transcription initiation site 5' untranslated region acute lymphoblastic leukemia antagonists and inhibitors biosynthesis child enhancer region gene expression regulation genetics Jurkat cell line metabolism nucleotide sequence oncogene myb point mutation RNA interference tumor cell line 5' Untranslated Regions APOBEC Deaminases Base Sequence Binding Sites Cell Line, Tumor Child Chromatin Immunoprecipitation DNA, Neoplasm DNA-Binding Proteins Enhancer Elements, Genetic Gene Expression Regulation, Leukemic Genes, myb Humans Jurkat Cells LIM Domain Proteins Neoplasm Proteins Point Mutation Polymorphism, Single Nucleotide Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Proto-Oncogene Proteins c-myb RNA Interference RNA, Small Interfering Transcription Factors Transcriptome Li, Z Abraham, B.J Berezovskaya, A Farah, N Liu, Y Leon, T Fielding, A Tan, S.H Sanda, T Weintraub, A.S Li, B Shen, S Zhang, J Mansour, M.R Young, R.A Look, A.T APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL
description	10.1038/leu.2017.75
author2	MEDICINE
author_facet	MEDICINE Li, Z Abraham, B.J Berezovskaya, A Farah, N Liu, Y Leon, T Fielding, A Tan, S.H Sanda, T Weintraub, A.S Li, B Shen, S Zhang, J Mansour, M.R Young, R.A Look, A.T
format	Article
author	Li, Z Abraham, B.J Berezovskaya, A Farah, N Liu, Y Leon, T Fielding, A Tan, S.H Sanda, T Weintraub, A.S Li, B Shen, S Zhang, J Mansour, M.R Young, R.A Look, A.T
author_sort	Li, Z
title	APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL
title_short	APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL
title_full	APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL
title_fullStr	APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL
title_full_unstemmed	APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL
title_sort	apobec signature mutation generates an oncogenic enhancer that drives lmo1 expression in t-all
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179091
_version_	1821190767175008256

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

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