NBEAL2 is required for neutrophil and NK cell function and pathogen defense

• Main Authors: Sowerby, J.M, Thomas, D.C, Clare, S, Espéli, M, Guerrero, J.A, Hoenderdos, K, Harcourt, K, Marsden, M, Abdul-Karim, J, Clement, M, Antrobus, R, Umrania, Y, Barton, P.R, Flint, S.M, Juss, J.K, Condliffe, A.M, Lyons, P.A, Humphreys, I.R, Chilvers, E.R, Ouwehand, W.H, Dougan, G, Smith, K.G.C
• Other Authors: MEDICINE
• Format: Article
• Published: American Society for Clinical Investigation 2020
• Subjects: reduced nicotinamide adenine dinucleotide phosphate oxidase; superoxide; NBEAL2 protein, human; plasma protein; animal cell; animal experiment; animal model; Article; cell function; Cytomegalovirus; cytomegalovirus infection; degranulation; gene; immune system; immunity; mouse; natural killer cell; nbeal2 gene; neutrophil; nonhuman; phagocyte; phenotype; priority journal; respiratory burst; Staphylococcus aureus; animal; cytosol; genetics; gray platelet syndrome; human; immunophenotyping; knockout mouse; metabolism; mutation; Staphylococcus infection; thrombocyte; Animals; Blood Platelets; Blood Proteins; Cytosol; Gray Platelet Syndrome; Humans; Immune System; Immunophenotyping; Killer Cells, Natural; Mice; Mice, Knockout; Mutation; NADPH Oxidase; Neutrophils; Phenotype; Staphylococcal Infections
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179095
• Institution: National University of Singapore

10.1172/JCI91684