Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation

• Main Authors: Mead, A.J, Neo, W.H, Barkas, N, Matsuoka, S, Giustacchini, A, Facchini, R, Thongjuea, S, Jamieson, L, Booth, C.A.G, Fordham, N, Di Genua, C, Atkinson, D, Chowdhury, O, Repapi, E, Gray, N, Kharazi, S, Clark, S.-A, Bouriez, T, Woll, P, Suda, T, Nerlov, C, Jacobsen, S.E.W
• Other Authors: MEDICINE
• Format: Article
• Published: Rockefeller University Press 2020
• Subjects: CD135 antigen; messenger RNA; tumor necrosis factor; etanercept; FLT3 protein, human; nonsteroid antiinflammatory agent; animal cell; Article; bone marrow stroma cell; endothelium cell; gene expression; hematopoietic stem cell; internal tandem duplication; mesenchymal stroma cell; mouse; myeloproliferative disorder; nonhuman; phenotype; priority journal; protein expression; single cell analysis; stem cell niche; tandem repeat; animal; antagonists and inhibitors; bone marrow cell; bone marrow transplantation; C57BL mouse; cell culture; cell proliferation; drug effects; gene expression profiling; genetics; metabolism; mutation; procedures; reverse transcription polymerase chain reaction; transgenic mouse; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Bone Marrow Transplantation; Cell Proliferation; Cells, Cultured; Etanercept; fms-Like Tyrosine Kinase 3; Gene Expression Profiling; Hematopoietic Stem Cells; Mesenchymal Stromal Cells; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Reverse Transcriptase Polymerase Chain Reaction; Single-Cell Analysis; Stem Cell Niche; Tandem Repeat Sequences; Tumor Necrosis Factor-alpha
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179194
• Institution: National University of Singapore

10.1084/jem.20161418