Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation
10.1084/jem.20161418
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2020
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sg-nus-scholar.10635-1791942024-11-13T19:59:20Z Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation Mead, A.J Neo, W.H Barkas, N Matsuoka, S Giustacchini, A Facchini, R Thongjuea, S Jamieson, L Booth, C.A.G Fordham, N Di Genua, C Atkinson, D Chowdhury, O Repapi, E Gray, N Kharazi, S Clark, S.-A Bouriez, T Woll, P Suda, T Nerlov, C Jacobsen, S.E.W MEDICINE CD135 antigen messenger RNA tumor necrosis factor CD135 antigen etanercept FLT3 protein, human nonsteroid antiinflammatory agent tumor necrosis factor animal cell Article bone marrow stroma cell endothelium cell gene expression hematopoietic stem cell internal tandem duplication mesenchymal stroma cell mouse myeloproliferative disorder nonhuman phenotype priority journal protein expression single cell analysis stem cell niche tandem repeat animal antagonists and inhibitors bone marrow cell bone marrow transplantation C57BL mouse cell culture cell proliferation drug effects gene expression profiling genetics hematopoietic stem cell metabolism mutation procedures reverse transcription polymerase chain reaction stem cell niche tandem repeat transgenic mouse Animals Anti-Inflammatory Agents, Non-Steroidal Bone Marrow Cells Bone Marrow Transplantation Cell Proliferation Cells, Cultured Etanercept fms-Like Tyrosine Kinase 3 Gene Expression Profiling Hematopoietic Stem Cells Mesenchymal Stromal Cells Mice, Inbred C57BL Mice, Transgenic Mutation Reverse Transcriptase Polymerase Chain Reaction Single-Cell Analysis Stem Cell Niche Tandem Repeat Sequences Tumor Necrosis Factor-alpha 10.1084/jem.20161418 Journal of Experimental Medicine 214 7 2005-2021 2020-10-23T02:27:28Z 2020-10-23T02:27:28Z 2017 Article Mead, A.J, Neo, W.H, Barkas, N, Matsuoka, S, Giustacchini, A, Facchini, R, Thongjuea, S, Jamieson, L, Booth, C.A.G, Fordham, N, Di Genua, C, Atkinson, D, Chowdhury, O, Repapi, E, Gray, N, Kharazi, S, Clark, S.-A, Bouriez, T, Woll, P, Suda, T, Nerlov, C, Jacobsen, S.E.W (2017). Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation. Journal of Experimental Medicine 214 (7) : 2005-2021. ScholarBank@NUS Repository. https://doi.org/10.1084/jem.20161418 00221007 https://scholarbank.nus.edu.sg/handle/10635/179194 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Rockefeller University Press Unpaywall 20201031 |
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CD135 antigen messenger RNA tumor necrosis factor CD135 antigen etanercept FLT3 protein, human nonsteroid antiinflammatory agent tumor necrosis factor animal cell Article bone marrow stroma cell endothelium cell gene expression hematopoietic stem cell internal tandem duplication mesenchymal stroma cell mouse myeloproliferative disorder nonhuman phenotype priority journal protein expression single cell analysis stem cell niche tandem repeat animal antagonists and inhibitors bone marrow cell bone marrow transplantation C57BL mouse cell culture cell proliferation drug effects gene expression profiling genetics hematopoietic stem cell metabolism mutation procedures reverse transcription polymerase chain reaction stem cell niche tandem repeat transgenic mouse Animals Anti-Inflammatory Agents, Non-Steroidal Bone Marrow Cells Bone Marrow Transplantation Cell Proliferation Cells, Cultured Etanercept fms-Like Tyrosine Kinase 3 Gene Expression Profiling Hematopoietic Stem Cells Mesenchymal Stromal Cells Mice, Inbred C57BL Mice, Transgenic Mutation Reverse Transcriptase Polymerase Chain Reaction Single-Cell Analysis Stem Cell Niche Tandem Repeat Sequences Tumor Necrosis Factor-alpha |
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CD135 antigen messenger RNA tumor necrosis factor CD135 antigen etanercept FLT3 protein, human nonsteroid antiinflammatory agent tumor necrosis factor animal cell Article bone marrow stroma cell endothelium cell gene expression hematopoietic stem cell internal tandem duplication mesenchymal stroma cell mouse myeloproliferative disorder nonhuman phenotype priority journal protein expression single cell analysis stem cell niche tandem repeat animal antagonists and inhibitors bone marrow cell bone marrow transplantation C57BL mouse cell culture cell proliferation drug effects gene expression profiling genetics hematopoietic stem cell metabolism mutation procedures reverse transcription polymerase chain reaction stem cell niche tandem repeat transgenic mouse Animals Anti-Inflammatory Agents, Non-Steroidal Bone Marrow Cells Bone Marrow Transplantation Cell Proliferation Cells, Cultured Etanercept fms-Like Tyrosine Kinase 3 Gene Expression Profiling Hematopoietic Stem Cells Mesenchymal Stromal Cells Mice, Inbred C57BL Mice, Transgenic Mutation Reverse Transcriptase Polymerase Chain Reaction Single-Cell Analysis Stem Cell Niche Tandem Repeat Sequences Tumor Necrosis Factor-alpha Mead, A.J Neo, W.H Barkas, N Matsuoka, S Giustacchini, A Facchini, R Thongjuea, S Jamieson, L Booth, C.A.G Fordham, N Di Genua, C Atkinson, D Chowdhury, O Repapi, E Gray, N Kharazi, S Clark, S.-A Bouriez, T Woll, P Suda, T Nerlov, C Jacobsen, S.E.W Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation |
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10.1084/jem.20161418 |
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MEDICINE |
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MEDICINE Mead, A.J Neo, W.H Barkas, N Matsuoka, S Giustacchini, A Facchini, R Thongjuea, S Jamieson, L Booth, C.A.G Fordham, N Di Genua, C Atkinson, D Chowdhury, O Repapi, E Gray, N Kharazi, S Clark, S.-A Bouriez, T Woll, P Suda, T Nerlov, C Jacobsen, S.E.W |
format |
Article |
author |
Mead, A.J Neo, W.H Barkas, N Matsuoka, S Giustacchini, A Facchini, R Thongjuea, S Jamieson, L Booth, C.A.G Fordham, N Di Genua, C Atkinson, D Chowdhury, O Repapi, E Gray, N Kharazi, S Clark, S.-A Bouriez, T Woll, P Suda, T Nerlov, C Jacobsen, S.E.W |
author_sort |
Mead, A.J |
title |
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation |
title_short |
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation |
title_full |
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation |
title_fullStr |
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation |
title_full_unstemmed |
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation |
title_sort |
niche-mediated depletion of the normal hematopoietic stem cell reservoir by flt3-itd-induced myeloproliferation |
publisher |
Rockefeller University Press |
publishDate |
2020 |
url |
https://scholarbank.nus.edu.sg/handle/10635/179194 |
_version_ |
1821212558493745152 |