The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression

10.1172/JCI83408

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Main Authors:	Whittaker, D.E, Riegman, K.L.H, Kasah, S, Mohan, C, Yu, T, Sala, B.P, Hebaishi, H, Caruso, A, Marques, A.C, Michetti, C, Smachetti, M.E.S, Shah, A, Sabbioni, M, Kulhanci, O, Tee, W.-W, Reinberg, D, Scattoni, M.L, Volk, H, McGonnell, I, Wardle, F.C, Fernandes, C, Basson, M.A
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	American Society for Clinical Investigation 2020
Subjects:	caspase reelin Chd7 protein, mouse DNA binding protein nerve cell adhesion molecule nerve protein reelin protein scleroprotein serine proteinase animal cell animal experiment animal model animal tissue Article brain development BrdU assay cell differentiation cell proliferation cell survival cerebellum cerebellum hypoplasia CHD7 gene chromatin assembly and disassembly chromatin immunoprecipitation controlled study developmental disorder experimental behavioral test female gene gene expression gene mutation immunohistochemistry in situ hybridization male motor coordination motor dysfunction mouse nonhuman polymerase chain reaction protein expression reelin gene Western blotting abnormalities animal embryology gene expression regulation gene locus genetics genome-wide association study human metabolism nervous system development nervous system malformation neural stem cell transgenic mouse Animals Cell Adhesion Molecules, Neuronal Cerebellum Developmental Disabilities DNA-Binding Proteins Extracellular Matrix Proteins Gene Expression Regulation, Developmental Genetic Loci Genome-Wide Association Study Humans Mice Mice, Transgenic Motor Disorders Nerve Tissue Proteins Nervous System Malformations Neural Stem Cells Neurogenesis Serine Endopeptidases
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179226
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1792262024-04-04T01:11:49Z The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression Whittaker, D.E Riegman, K.L.H Kasah, S Mohan, C Yu, T Sala, B.P Hebaishi, H Caruso, A Marques, A.C Michetti, C Smachetti, M.E.S Shah, A Sabbioni, M Kulhanci, O Tee, W.-W Reinberg, D Scattoni, M.L Volk, H McGonnell, I Wardle, F.C Fernandes, C Basson, M.A PHYSIOLOGY caspase reelin Chd7 protein, mouse DNA binding protein nerve cell adhesion molecule nerve protein reelin protein scleroprotein serine proteinase animal cell animal experiment animal model animal tissue Article brain development BrdU assay cell differentiation cell proliferation cell survival cerebellum cerebellum hypoplasia CHD7 gene chromatin assembly and disassembly chromatin immunoprecipitation controlled study developmental disorder experimental behavioral test female gene gene expression gene mutation immunohistochemistry in situ hybridization male motor coordination motor dysfunction mouse nonhuman polymerase chain reaction protein expression reelin gene Western blotting abnormalities animal cerebellum embryology gene expression regulation gene locus genetics genome-wide association study human metabolism nervous system development nervous system malformation neural stem cell transgenic mouse Animals Cell Adhesion Molecules, Neuronal Cerebellum Developmental Disabilities DNA-Binding Proteins Extracellular Matrix Proteins Gene Expression Regulation, Developmental Genetic Loci Genome-Wide Association Study Humans Mice Mice, Transgenic Motor Disorders Nerve Tissue Proteins Nervous System Malformations Neural Stem Cells Neurogenesis Serine Endopeptidases 10.1172/JCI83408 Journal of Clinical Investigation 127 3 874-887 2020-10-23T02:32:44Z 2020-10-23T02:32:44Z 2017 Article Whittaker, D.E, Riegman, K.L.H, Kasah, S, Mohan, C, Yu, T, Sala, B.P, Hebaishi, H, Caruso, A, Marques, A.C, Michetti, C, Smachetti, M.E.S, Shah, A, Sabbioni, M, Kulhanci, O, Tee, W.-W, Reinberg, D, Scattoni, M.L, Volk, H, McGonnell, I, Wardle, F.C, Fernandes, C, Basson, M.A (2017). The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression. Journal of Clinical Investigation 127 (3) : 874-887. ScholarBank@NUS Repository. https://doi.org/10.1172/JCI83408 00219738 https://scholarbank.nus.edu.sg/handle/10635/179226 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ American Society for Clinical Investigation Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	caspase reelin Chd7 protein, mouse DNA binding protein nerve cell adhesion molecule nerve protein reelin protein scleroprotein serine proteinase animal cell animal experiment animal model animal tissue Article brain development BrdU assay cell differentiation cell proliferation cell survival cerebellum cerebellum hypoplasia CHD7 gene chromatin assembly and disassembly chromatin immunoprecipitation controlled study developmental disorder experimental behavioral test female gene gene expression gene mutation immunohistochemistry in situ hybridization male motor coordination motor dysfunction mouse nonhuman polymerase chain reaction protein expression reelin gene Western blotting abnormalities animal cerebellum embryology gene expression regulation gene locus genetics genome-wide association study human metabolism nervous system development nervous system malformation neural stem cell transgenic mouse Animals Cell Adhesion Molecules, Neuronal Cerebellum Developmental Disabilities DNA-Binding Proteins Extracellular Matrix Proteins Gene Expression Regulation, Developmental Genetic Loci Genome-Wide Association Study Humans Mice Mice, Transgenic Motor Disorders Nerve Tissue Proteins Nervous System Malformations Neural Stem Cells Neurogenesis Serine Endopeptidases
spellingShingle	caspase reelin Chd7 protein, mouse DNA binding protein nerve cell adhesion molecule nerve protein reelin protein scleroprotein serine proteinase animal cell animal experiment animal model animal tissue Article brain development BrdU assay cell differentiation cell proliferation cell survival cerebellum cerebellum hypoplasia CHD7 gene chromatin assembly and disassembly chromatin immunoprecipitation controlled study developmental disorder experimental behavioral test female gene gene expression gene mutation immunohistochemistry in situ hybridization male motor coordination motor dysfunction mouse nonhuman polymerase chain reaction protein expression reelin gene Western blotting abnormalities animal cerebellum embryology gene expression regulation gene locus genetics genome-wide association study human metabolism nervous system development nervous system malformation neural stem cell transgenic mouse Animals Cell Adhesion Molecules, Neuronal Cerebellum Developmental Disabilities DNA-Binding Proteins Extracellular Matrix Proteins Gene Expression Regulation, Developmental Genetic Loci Genome-Wide Association Study Humans Mice Mice, Transgenic Motor Disorders Nerve Tissue Proteins Nervous System Malformations Neural Stem Cells Neurogenesis Serine Endopeptidases Whittaker, D.E Riegman, K.L.H Kasah, S Mohan, C Yu, T Sala, B.P Hebaishi, H Caruso, A Marques, A.C Michetti, C Smachetti, M.E.S Shah, A Sabbioni, M Kulhanci, O Tee, W.-W Reinberg, D Scattoni, M.L Volk, H McGonnell, I Wardle, F.C Fernandes, C Basson, M.A The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression
description	10.1172/JCI83408
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Whittaker, D.E Riegman, K.L.H Kasah, S Mohan, C Yu, T Sala, B.P Hebaishi, H Caruso, A Marques, A.C Michetti, C Smachetti, M.E.S Shah, A Sabbioni, M Kulhanci, O Tee, W.-W Reinberg, D Scattoni, M.L Volk, H McGonnell, I Wardle, F.C Fernandes, C Basson, M.A
format	Article
author	Whittaker, D.E Riegman, K.L.H Kasah, S Mohan, C Yu, T Sala, B.P Hebaishi, H Caruso, A Marques, A.C Michetti, C Smachetti, M.E.S Shah, A Sabbioni, M Kulhanci, O Tee, W.-W Reinberg, D Scattoni, M.L Volk, H McGonnell, I Wardle, F.C Fernandes, C Basson, M.A
author_sort	Whittaker, D.E
title	The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression
title_short	The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression
title_full	The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression
title_fullStr	The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression
title_full_unstemmed	The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression
title_sort	chromatin remodeling factor chd7 controls cerebellar development by regulating reelin expression
publisher	American Society for Clinical Investigation
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179226
_version_	1795374478567407616

The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression

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